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Item

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Doxorubicin-Loaded Carboxymethyl Cellulose/Chitosan/ZnO Nanocomposite Hydrogel Beads as an Anticancer Drug Carrier Agent

https://meral.edu.mm/records/9412
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6dc35ca8-67d4-4b33-9dfe-4f4ce56e6081
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1-DrAungThanHtwe.pdf 1-DrAungThanHtwe.pdf (1.1 MB)
Publication type
Journal article
Upload type
Publication
Title
Title Doxorubicin-Loaded Carboxymethyl Cellulose/Chitosan/ZnO Nanocomposite Hydrogel Beads as an Anticancer Drug Carrier Agent
Language en
Publication date 2023-12-31
Authors
Aung Than Htwe
Hninn Wutt Yee Htun
Yamin Thet
May Thazin Kyaw
Ngwe Sin
Win Pa Pa Phyo
Cho Cho
Description
Abstract
In this study, nanocomposite hydrogel beads were prepared by combining carboxymethyl cellulose (CMC), chitosan (CS), and ZnO nanoparticles (ZnO NPs). The obtained nanocomposite hydrogel beads were used as a potential candidate for controlled release of anticancer drug doxorubicin (DOX). The nanocomposite hydrogel beads were characterized using FT-IR, XRD, UV–vis, SEM, TG-DTA analysis. Then antimicrobial activity of the nanocomposite hydrogel beads was tested for the purpose of using nanocomposite hydrogel beads in biomedical application. In addition, gel content, swelling properties, and drug release of the samples were evaluated. The swelling and drug release profiles revealed that the amount of drug released and swelling of the hydrogels depended on the CMC/CS content, pH, and ZnO nanoparticle content. Prolonged and more controlled drug releases were observed for ZnO nanoparticle containing CMC/CS beads, which increased with the rise in ZnO nanoparticle content.
Keywords
nanocomposite hydrogel beads, carboxymethyl cellulose, chitosan, ZnO nanoparticles, drug release
Journal articles
2023
Journal of Asia Research Centre University of Yangon
1-17
Vol.9, No.1 & 2, 2023
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0
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