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"Structural Identification and Evaluation of Some Biological Activities of Cyclo (D-Pro-L-Val) from thePseudomonas aeruginosa Schroeter"
https://meral.edu.mm/records/8411
https://meral.edu.mm/records/8411f058fc8b-122a-47db-a3d0-5fcafb26ca55
7dbbb829-92e8-4ea2-a8f7-1d0701d01b85
Name / File | License | Actions |
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Su Swe Su.pdf (694 KB)
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Publication type | ||||||
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Journal article | ||||||
Upload type | ||||||
Publication | ||||||
Title | ||||||
Title | "Structural Identification and Evaluation of Some Biological Activities of Cyclo (D-Pro-L-Val) from thePseudomonas aeruginosa Schroeter" | |||||
Language | en | |||||
Publication date | 2022-08-12 | |||||
Authors | ||||||
Su Swe Su | ||||||
Suu Suu Win | ||||||
Chaw Theingi Khin | ||||||
Description | ||||||
"This research deals with the studies of identification and evaluation of some biological activities of bioactive secondary metabolite compound of Pseudomonas aeruginosa isolated from the clinical soil sample. The soil sample was collected from Insein General Hospital, Yangon Region. The isolated P. aeruginosa strain was characterized by microscopic examination, biochemical tests and confirmed by 16S rRNA sequencing technique. The chloroform extract was prepared from the P. aeruginosa cultured in a large scale of nutrient broth medium.Diketopiperazines, such as, cyclo-(D-Pro-L-Val) was isolatedfrom the silica gel chromatographic separation on the chloroform extract. The isolated secondary metabolite was structurally identified by using modern NMR spectroscopic techniques such as 1H NMR(Proton Nuclear Magnetic Resonance) , 13C NMR (Carbon-13 Nuclear Magnetic Resonance spectroscopy), COSY (¹H-¹H Correlation Spectroscopy), HSQC (Heteronuclear Single Quantum Coherence), ROESY (Rotating frame Overhause Effect Spectroscopy), HMBC spectroscopies (Heteronuclear Multiple Bond Correlation), and MS (mass spectrometry). The isolated compound, cyclo(D-Pro-L-Val) (IC50 = 0.93 μg /mL) was found to exhibit good in vitro cytotoxic activity against human lung cancercell A-549. In addition, cyclo(D-Pro-LVal) (IC50 = 64.12 μM) has mild inhibited in anti-inflammatoryactivity." |
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Keywords | ||||||
"cyclo(D-Pro-L-Val), modern NMR spectroscopic techniques, in vitro cytotoxicity activity and anti-inflammatoryactivity | ||||||
Journal articles | ||||||
2022 | ||||||
Yadanabon University Research Journal | ||||||
211-219 | ||||||
Vol.12, No.1 |