MERAL Myanmar Education Research and Learning Portal
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Insulin Receptor Substrate-1 Gene (G972R) Polymorphism and Insulin Resistance in Overweight and Obese Type 2 Diabetes Mellitus Patients
http://hdl.handle.net/20.500.12678/0000003194
http://hdl.handle.net/20.500.12678/0000003194bb868d91-9d74-4e0a-8866-891a45ec5586
82f925d9-5af7-40e1-a50b-b1dc291ad79f
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Insulin Receptor Substrate-1 Gene (G972R) Polymorphism and Insulin Resistance.pdf (132 Kb)
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Journal article | ||||||
Upload type | ||||||
Publication | ||||||
Title | ||||||
Title | Insulin Receptor Substrate-1 Gene (G972R) Polymorphism and Insulin Resistance in Overweight and Obese Type 2 Diabetes Mellitus Patients | |||||
Publication date | 2015-12-24 | |||||
Authors | ||||||
Thae Nu Htwe | ||||||
Myat Mon Oo | ||||||
Saw Wut Hmon | ||||||
Moh Moh Htun | ||||||
Ohnmar Myint Thein | ||||||
Myat Thandar | ||||||
Description | ||||||
<p>The insulin receptor substrate-1 gene (IRS-1) gene has been considered a candidate for insulin resistance in type-2 diabetes and coronary artery disease. The most common IRS-1 variant, a glycine to arginine change at codon 972(G972R) is more prevalent among subjects who have features of insulin resistance syndrome associated with type 2 diabetes patients. The aim of the present study was to determine the insulin receptor substrate-1 gene (G972R) polymorphism and insulin resistance in overweight and obese type 2 diabetes mellitus patients. The genomic DNA of the subjects was amplified by polymerase chain reaction (PCR) and digested by restriction fragment length polymorphism (RFLP) with BstN1 used for codon 972.</p> | ||||||
Keywords | ||||||
IRS-1gene, G972R, Polymorphism, T2DM | ||||||
Identifier | 10.5281/zenodo.3745901 | |||||
Journal articles | ||||||
1 | ||||||
Myanmar Health Sciences Research Journal | ||||||
66-71 | ||||||
27 | ||||||
Conference papers | ||||||
Books/reports/chapters | ||||||
Thesis/dissertations |