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Cyclooxygenase-2 (COX-2) enzyme and its products; prostaglandin, prostacyclin, thromboxane are involved in inflammation. The aim of the study was to determine the association between serum EGFR and cyclooxygenase-2 levels in patients with NSCLC and healthy controls. It was a cross-sectional analytic study. This study included 53 patients diagnosed as NSCLC (3 adenocarcinoma and 50 squamous cell carcinoma (SCC) of lung patients) and 16 apparently controls. Serum EGFR and COX-2 levels were determined by ELISA.\u003cbr\u003e\nSerum EGFR levels of healthy controls and NSCLC patients were 3.56\u0026plusmn;0.48 ng/ml and 170.10\u0026plusmn;13.80 ng/ml, respectively. In patients with NSCLC, serum EGFR of SCC and adenocarcinoma lung were 172.10\u0026plusmn;14.30 ng/ml and 137.40 \u0026plusmn;64.70 ng/ml, respectively. Serum COX-2 levels of healthy controls and NSCLC patients were 0.62\u0026plusmn;0.15 ng/ml and 13.21\u0026plusmn;3.17 ng/ml. In patients with NSCLC, serum COX-2 levels of SCC and adenocarcinoma lung were 13.60\u0026plusmn;3.34 ng/ml and 6.69\u0026plusmn;5.52 ng/ml, respectively.\u003cbr\u003e\nThere is a significant association between serum EGFR and COX-2 levels in NSCLC patients (X2 = 7.854, p = 0.005). Mean level of serum EGFR (170.10 ng/ml) and COX-2 (13.21 ng/ml) are set as cut off values for categorization of low and high groups. There was no correlation between serum EGFR and COX-2 in healthy controls (r = -0.036, p = 0.894) and NSCLC patients (r = 0.161, p = 0.250). After excluding 4 outliers, the correlation between serum EGFR and COX-2 levels in NSCLC patients became significant (r = 0.454, p = 0.001). Correlation between serum EGFR and COX-2 levels in SCC patients was not significant statistically (r = 0.142, p = 0.325) but after excluding the 4 outliers, it became significant statistically (r = 0.418, p = 0.004). There was positive correlation in adenocarcinoma (r = 0.999, p = 0.021). These findings indicated that EGFR and COX-2 play an important role in carcinogenesis of lung and are positively associated.\u003c/p\u003e"}]}, "item_1583103108160": {"attribute_name": "Keywords", "attribute_value": []}, "item_1583103120197": {"attribute_name": "Files", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2020-02-21"}], "displaytype": "preview", "download_preview_message": "", "file_order": 0, "filename": "Association between Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung.pdf", "filesize": [{"value": "367 Kb"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_0", "mimetype": "application/pdf", "size": 367000.0, "url": {"url": "https://meral.edu.mm/record/3173/files/Association between Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung.pdf"}, "version_id": "73abd7ed-fcb7-4873-92c8-49775e314d93"}]}, "item_1583103131163": {"attribute_name": "Journal articles", "attribute_value_mlt": [{"subitem_issue": "2", "subitem_journal_title": "Myanmar Health Research Jounral", "subitem_pages": "1-6", "subitem_volume": "28"}]}, "item_1583103147082": {"attribute_name": "Conference papers", "attribute_value_mlt": [{"subitem_acronym": "", "subitem_c_date": "", "subitem_conference_title": "", "subitem_part": "", "subitem_place": "", "subitem_session": "", "subitem_website": ""}]}, "item_1583103211336": {"attribute_name": "Books/reports/chapters", "attribute_value_mlt": [{"subitem_book_title": "", "subitem_isbn": "", "subitem_pages": "", "subitem_place": "", "subitem_publisher": ""}]}, "item_1583103233624": {"attribute_name": "Thesis/dissertations", "attribute_value_mlt": [{"subitem_awarding_university": "", "subitem_supervisor(s)": [{"subitem_supervisor": ""}]}]}, "item_1583105942107": {"attribute_name": "Authors", "attribute_value_mlt": [{"subitem_authors": [{"subitem_authors_fullname": "Thuzar Kyin Aung"}, {"subitem_authors_fullname": "Htar Kyi Sunn"}, {"subitem_authors_fullname": "Theingi Myint"}]}]}, "item_1583108359239": {"attribute_name": "Upload type", "attribute_value_mlt": [{"interim": "Publication"}]}, "item_1583108428133": {"attribute_name": "Publication type", "attribute_value_mlt": [{"interim": "Journal article"}]}, "item_1583159729339": {"attribute_name": "Publication date", "attribute_value": "2016-08-04"}, "item_1583159847033": {"attribute_name": "Identifier", "attribute_value": "10.5281/zenodo.3678114"}, "item_title": "Association between Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung", "item_type_id": "21", "owner": "1", "path": ["1597649530495"], "permalink_uri": "http://hdl.handle.net/20.500.12678/0000003173", "pubdate": {"attribute_name": "Deposited date", "attribute_value": "2020-02-21"}, "publish_date": "2020-02-21", "publish_status": "0", "recid": "3173", "relation": {}, "relation_version_is_last": true, "title": ["Association between Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung"], "weko_shared_id": -1}
Association between Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung
http://hdl.handle.net/20.500.12678/0000003173
http://hdl.handle.net/20.500.12678/00000031737b6940b5-e1cd-454c-b936-69f766afb5f6
269f6742-464d-4b0c-8be0-a763f4e6e4e4
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Association between Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung.pdf (367 Kb)
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