{"created":"2020-08-30T20:05:15.873980+00:00","id":3173,"links":{},"metadata":{"_buckets":{"deposit":"269f6742-464d-4b0c-8be0-a763f4e6e4e4"},"_deposit":{"id":"3173","owners":[],"pid":{"revision_id":0,"type":"recid","value":"3173"},"status":"published"},"_oai":{"id":"oai:meral.edu.mm:recid/3173","sets":["1582963366982:1597649530495"]},"communities":["um1"],"item_1583103067471":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Association between Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung","subitem_1551255648112":""}]},"item_1583103085720":{"attribute_name":"Description","attribute_value_mlt":[{"interim":"<p>Relation of inflammation and cancer can be proven in most of the studies. Epidermal growth factor receptor (EGFR) overexpression is one of the commonest causes of non-small cell carcinoma of lung cancer (NSCLC). Cyclooxygenase-2 (COX-2) enzyme and its products; prostaglandin, prostacyclin, thromboxane are involved in inflammation. The aim of the study was to determine the association between serum EGFR and cyclooxygenase-2 levels in patients with NSCLC and healthy controls. It was a cross-sectional analytic study. This study included 53 patients diagnosed as NSCLC (3 adenocarcinoma and 50 squamous cell carcinoma (SCC) of lung patients) and 16 apparently controls. Serum EGFR and COX-2 levels were determined by ELISA.<br>\nSerum EGFR levels of healthy controls and NSCLC patients were 3.56&plusmn;0.48 ng/ml and 170.10&plusmn;13.80 ng/ml, respectively. In patients with NSCLC, serum EGFR of SCC and adenocarcinoma lung were 172.10&plusmn;14.30 ng/ml and 137.40 &plusmn;64.70 ng/ml, respectively. Serum COX-2 levels of healthy controls and NSCLC patients were 0.62&plusmn;0.15 ng/ml and 13.21&plusmn;3.17 ng/ml. In patients with NSCLC, serum COX-2 levels of SCC and adenocarcinoma lung were 13.60&plusmn;3.34 ng/ml and 6.69&plusmn;5.52 ng/ml, respectively.<br>\nThere is a significant association between serum EGFR and COX-2 levels in NSCLC patients (X2 = 7.854, p = 0.005). Mean level of serum EGFR (170.10 ng/ml) and COX-2 (13.21 ng/ml) are set as cut off values for categorization of low and high groups. There was no correlation between serum EGFR and COX-2 in healthy controls (r = -0.036, p = 0.894) and NSCLC patients (r = 0.161, p = 0.250). After excluding 4 outliers, the correlation between serum EGFR and COX-2 levels in NSCLC patients became significant (r = 0.454, p = 0.001). Correlation between serum EGFR and COX-2 levels in SCC patients was not significant statistically (r = 0.142, p = 0.325) but after excluding the 4 outliers, it became significant statistically (r = 0.418, p = 0.004). There was positive correlation in adenocarcinoma (r = 0.999, p = 0.021). These findings indicated that EGFR and COX-2 play an important role in carcinogenesis of lung and are positively associated.</p>"}]},"item_1583103108160":{"attribute_name":"Keywords","attribute_value":[]},"item_1583103120197":{"attribute_name":"Files","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-02-21"}],"displaytype":"preview","filename":"Association between Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung.pdf","filesize":[{"value":"367 Kb"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"url":"https://meral.edu.mm/record/3173/files/Association between Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung.pdf"},"version_id":"73abd7ed-fcb7-4873-92c8-49775e314d93"}]},"item_1583103131163":{"attribute_name":"Journal articles","attribute_value_mlt":[{"subitem_issue":"2","subitem_journal_title":"Myanmar Health Research Jounral","subitem_pages":"1-6","subitem_volume":"28"}]},"item_1583103147082":{"attribute_name":"Conference papers","attribute_value_mlt":[{"subitem_acronym":"","subitem_c_date":"","subitem_conference_title":"","subitem_part":"","subitem_place":"","subitem_session":"","subitem_website":""}]},"item_1583103211336":{"attribute_name":"Books/reports/chapters","attribute_value_mlt":[{"subitem_book_title":"","subitem_isbn":"","subitem_pages":"","subitem_place":"","subitem_publisher":""}]},"item_1583103233624":{"attribute_name":"Thesis/dissertations","attribute_value_mlt":[{"subitem_awarding_university":"","subitem_supervisor(s)":[{"subitem_supervisor":""}]}]},"item_1583105942107":{"attribute_name":"Authors","attribute_value_mlt":[{"subitem_authors":[{"subitem_authors_fullname":"Thuzar Kyin Aung"},{"subitem_authors_fullname":"Htar Kyi Sunn"},{"subitem_authors_fullname":"Theingi Myint"}]}]},"item_1583108359239":{"attribute_name":"Upload type","attribute_value_mlt":[{"interim":"Publication"}]},"item_1583108428133":{"attribute_name":"Publication type","attribute_value_mlt":[{"interim":"Journal article"}]},"item_1583159729339":{"attribute_name":"Publication date","attribute_value":"2016-08-04"},"item_1583159847033":{"attribute_name":"Identifier","attribute_value":"10.5281/zenodo.3678114"},"item_title":"Association between Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung","item_type_id":"21","owner":"1","path":["1597649530495"],"publish_date":"2020-02-21","publish_status":"0","recid":"3173","relation_version_is_last":true,"title":["Association between Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-03-24T23:11:18.866046+00:00"}