{"_buckets": {"deposit": "7fb6112c-a1b1-42c7-b383-c0ba51380b80"}, "_deposit": {"id": "3154", "owners": [], "pid": {"revision_id": 0, "type": "recid", "value": "3154"}, "status": "published"}, "_oai": {"id": "oai:meral.edu.mm:recid/3154", "sets": ["user-um1"]}, "communities": ["um1"], "item_1583103067471": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Effect of Cyp2c19*2 Polymorphism on the Pharmacokinetics  of Gliclazide in Healthy Myanmar Volunteers", "subitem_1551255648112": ""}]}, "item_1583103085720": {"attribute_name": "Description", "attribute_value_mlt": [{"interim": "\u003cp\u003eThis study aimed to determine the effect of CYP2C19*2 polymorphism on\u0026nbsp;the pharmacokinetics of gliclazide in healthy Myanmar volunteers. In the\u0026nbsp;phase I study, a total of 150 subjects, of either sex of different ethnicities,\u0026nbsp;were randomly selected for determination of CYP2C19 genotype. Among\u0026nbsp;them, 53.3% were normal/wild type, 40% were heterozygous and 6.67%\u0026nbsp;were homozygous for CYP2C19*2 genotype. In the phase II study, one\u0026nbsp;tablet of Reclide containing 80 mg of gliclazide was given to each volunteer\u0026nbsp;and blood samples were collected at 0, 1, 2, 3, 4, 5, 6, 8, 10 and 24 hr after\u0026nbsp;drug administration. Plasma gliclazide concentrations were determined\u0026nbsp;by validated HPLC method and the pharmacokinetic parameters were\u0026nbsp;compared among three different genotypes.\u003c/p\u003e"}]}, "item_1583103108160": {"attribute_name": "Keywords", "attribute_value": []}, "item_1583103120197": {"attribute_name": "Files", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2019-11-14"}], "displaytype": "preview", "download_preview_message": "", "file_order": 0, "filename": "Myanmar Health Science Research Journal .pdf", "filesize": [{"value": "857 Kb"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_0", "mimetype": "application/pdf", "size": 857000.0, "url": {"url": "https://meral.edu.mm/record/3154/files/Myanmar Health Science Research Journal .pdf"}, "version_id": "c2ee423d-c0e8-4ab0-89b3-4ee987820360"}]}, "item_1583103131163": {"attribute_name": "Journal articles", "attribute_value_mlt": [{"subitem_issue": "2", "subitem_journal_title": "Myanmar Health Sciences Research Journal", "subitem_pages": "83-89", "subitem_volume": "28"}]}, "item_1583103147082": {"attribute_name": "Conference papers", "attribute_value_mlt": [{"subitem_acronym": "", "subitem_c_date": "", "subitem_conference_title": "", "subitem_part": "", "subitem_place": "", "subitem_session": "", "subitem_website": ""}]}, "item_1583103211336": {"attribute_name": "Books/reports/chapters", "attribute_value_mlt": [{"subitem_book_title": "", "subitem_isbn": "", "subitem_pages": "", "subitem_place": "", "subitem_publisher": ""}]}, "item_1583103233624": {"attribute_name": "Thesis/dissertations", "attribute_value_mlt": [{"subitem_awarding_university": "", "subitem_supervisor(s)": [{"subitem_supervisor": ""}]}]}, "item_1583105942107": {"attribute_name": "Authors", "attribute_value_mlt": [{"subitem_authors": [{"subitem_authors_fullname": "Latt Latt Win"}, {"subitem_authors_fullname": "Nang Hla Hla Win"}, {"subitem_authors_fullname": "Ne Win"}, {"subitem_authors_fullname": "Aye Khine Nyun"}, {"subitem_authors_fullname": "Swe Setk"}]}]}, "item_1583108359239": {"attribute_name": "Upload type", "attribute_value_mlt": [{"interim": "Publication"}]}, "item_1583108428133": {"attribute_name": "Publication type", "attribute_value_mlt": [{"interim": "Journal article"}]}, "item_1583159729339": {"attribute_name": "Publication date", "attribute_value": "2016-09-21"}, "item_1583159847033": {"attribute_name": "Identifier", "attribute_value": "10.5281/zenodo.3541534"}, "item_title": "Effect of Cyp2c19*2 Polymorphism on the Pharmacokinetics  of Gliclazide in Healthy Myanmar Volunteers", "item_type_id": "21", "owner": "1", "path": ["1596631759527"], "permalink_uri": "http://hdl.handle.net/20.500.12678/0000003154", "pubdate": {"attribute_name": "Deposited date", "attribute_value": "2019-11-14"}, "publish_date": "2019-11-14", "publish_status": "0", "recid": "3154", "relation": {}, "relation_version_is_last": true, "title": ["Effect of Cyp2c19*2 Polymorphism on the Pharmacokinetics  of Gliclazide in Healthy Myanmar Volunteers"], "weko_shared_id": -1}