{"created":"2020-08-30T20:02:57.482811+00:00","id":3154,"links":{},"metadata":{"_buckets":{"deposit":"7fb6112c-a1b1-42c7-b383-c0ba51380b80"},"_deposit":{"id":"3154","owners":[],"pid":{"revision_id":0,"type":"recid","value":"3154"},"status":"published"},"_oai":{"id":"oai:meral.edu.mm:recid/3154","sets":["1582963366982:1596631759527"]},"communities":["um1"],"item_1583103067471":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Effect of Cyp2c19*2 Polymorphism on the Pharmacokinetics  of Gliclazide in Healthy Myanmar Volunteers","subitem_1551255648112":""}]},"item_1583103085720":{"attribute_name":"Description","attribute_value_mlt":[{"interim":"<p>This study aimed to determine the effect of CYP2C19*2 polymorphism on&nbsp;the pharmacokinetics of gliclazide in healthy Myanmar volunteers. In the&nbsp;phase I study, a total of 150 subjects, of either sex of different ethnicities,&nbsp;were randomly selected for determination of CYP2C19 genotype. Among&nbsp;them, 53.3% were normal/wild type, 40% were heterozygous and 6.67%&nbsp;were homozygous for CYP2C19*2 genotype. In the phase II study, one&nbsp;tablet of Reclide containing 80 mg of gliclazide was given to each volunteer&nbsp;and blood samples were collected at 0, 1, 2, 3, 4, 5, 6, 8, 10 and 24 hr after&nbsp;drug administration. Plasma gliclazide concentrations were determined&nbsp;by validated HPLC method and the pharmacokinetic parameters were&nbsp;compared among three different genotypes.</p>"}]},"item_1583103108160":{"attribute_name":"Keywords","attribute_value":[]},"item_1583103120197":{"attribute_name":"Files","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-11-14"}],"displaytype":"preview","filename":"Myanmar Health Science Research Journal .pdf","filesize":[{"value":"857 Kb"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"url":"https://meral.edu.mm/record/3154/files/Myanmar Health Science Research Journal .pdf"},"version_id":"c2ee423d-c0e8-4ab0-89b3-4ee987820360"}]},"item_1583103131163":{"attribute_name":"Journal articles","attribute_value_mlt":[{"subitem_issue":"2","subitem_journal_title":"Myanmar Health Sciences Research Journal","subitem_pages":"83-89","subitem_volume":"28"}]},"item_1583103147082":{"attribute_name":"Conference papers","attribute_value_mlt":[{"subitem_acronym":"","subitem_c_date":"","subitem_conference_title":"","subitem_part":"","subitem_place":"","subitem_session":"","subitem_website":""}]},"item_1583103211336":{"attribute_name":"Books/reports/chapters","attribute_value_mlt":[{"subitem_book_title":"","subitem_isbn":"","subitem_pages":"","subitem_place":"","subitem_publisher":""}]},"item_1583103233624":{"attribute_name":"Thesis/dissertations","attribute_value_mlt":[{"subitem_awarding_university":"","subitem_supervisor(s)":[{"subitem_supervisor":""}]}]},"item_1583105942107":{"attribute_name":"Authors","attribute_value_mlt":[{"subitem_authors":[{"subitem_authors_fullname":"Latt Latt Win"},{"subitem_authors_fullname":"Nang Hla Hla Win"},{"subitem_authors_fullname":"Ne Win"},{"subitem_authors_fullname":"Aye Khine Nyun"},{"subitem_authors_fullname":"Swe Setk"}]}]},"item_1583108359239":{"attribute_name":"Upload type","attribute_value_mlt":[{"interim":"Publication"}]},"item_1583108428133":{"attribute_name":"Publication type","attribute_value_mlt":[{"interim":"Journal article"}]},"item_1583159729339":{"attribute_name":"Publication date","attribute_value":"2016-09-21"},"item_1583159847033":{"attribute_name":"Identifier","attribute_value":"10.5281/zenodo.3541534"},"item_title":"Effect of Cyp2c19*2 Polymorphism on the Pharmacokinetics  of Gliclazide in Healthy Myanmar Volunteers","item_type_id":"21","owner":"1","path":["1596631759527"],"publish_date":"2019-11-14","publish_status":"0","recid":"3154","relation_version_is_last":true,"title":["Effect of Cyp2c19*2 Polymorphism on the Pharmacokinetics  of Gliclazide in Healthy Myanmar Volunteers"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2021-12-13T02:50:39.564481+00:00"}