{"_buckets": {"deposit": "16b78398-01d9-430d-9f8f-2a3d29483ac5"}, "_deposit": {"id": "3140", "owners": [], "pid": {"revision_id": 0, "type": "recid", "value": "3140"}, "status": "published"}, "_oai": {"id": "oai:meral.edu.mm:recid/3140", "sets": ["user-um1"]}, "communities": ["um1"], "item_1583103067471": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines", "subitem_1551255648112": ""}]}, "item_1583103085720": {"attribute_name": "Description", "attribute_value_mlt": [{"interim": "\u003cp\u003eCatestatin, a neuroendocrine peptide with effects on human autonomic\u0026nbsp;function, has recently been found to be a cutaneous antimicrobial peptide.\u0026nbsp;Human catestatin exhibits three single nucleotide polymorphisms: Gly364-\u0026nbsp;Ser, Pro370Leu and Arg374Gln. Given reports indicating that antimicrobial\u0026nbsp;peptides and neuropeptides induce mast cell activation, we postulated\u0026nbsp;that catestatin might stimulate numerous functions of human mast cells,\u0026nbsp;thereby participating in the regulation of skin inflammatory responses.\u0026nbsp;Catestatin and its naturally occurring variants caused the human mast cell\u0026nbsp;line LAD2 and peripheral blood-derived mast cells to migrate, degranulate\u0026nbsp;and release leukotriene C4 and prostaglandins D2 and E2. Moreover,\u0026nbsp;catestatins increased intracellular Ca2+ mobilization in mast cells, and\u0026nbsp;induced the production of pro-inflammatory cytokines/chemokines such\u0026nbsp;as granulocyte\u0026ndash;macrophage colony-stimulating factor, monocyte chemotactic\u0026nbsp;protein-1/CCL2, macrophage inflammatory protein-1a/CCL3 and\u003cbr\u003e\nmacrophage inflammatory protein-1b/CCL4.\u003c/p\u003e"}]}, "item_1583103108160": {"attribute_name": "Keywords", "attribute_value": []}, "item_1583103120197": {"attribute_name": "Files", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2019-10-10"}], "displaytype": "preview", "download_preview_message": "", "file_order": 0, "filename": "Catestatin, a neuroendocrine antimicrobial peptide, induces human.pdf", "filesize": [{"value": "602 Kb"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_0", "mimetype": "application/pdf", "size": 602000.0, "url": {"url": "https://meral.edu.mm/record/3140/files/Catestatin, a neuroendocrine antimicrobial peptide, induces human.pdf"}, "version_id": "69bb55d8-8f8c-4392-9ba6-0732d2bfd15f"}]}, "item_1583103131163": {"attribute_name": "Journal articles", "attribute_value_mlt": [{"subitem_issue": "", "subitem_journal_title": "Immunology: The Journal of Cells, Molecular, Systems and Technologies", "subitem_pages": "1-13", "subitem_volume": ""}]}, "item_1583103147082": {"attribute_name": "Conference papers", "attribute_value_mlt": [{"subitem_acronym": "", "subitem_c_date": "", "subitem_conference_title": "", "subitem_part": "", "subitem_place": "", "subitem_session": "", "subitem_website": ""}]}, "item_1583103211336": {"attribute_name": "Books/reports/chapters", "attribute_value_mlt": [{"subitem_book_title": "", "subitem_isbn": "", "subitem_pages": "", "subitem_place": "", "subitem_publisher": ""}]}, "item_1583103233624": {"attribute_name": "Thesis/dissertations", "attribute_value_mlt": [{"subitem_awarding_university": "", "subitem_supervisor(s)": [{"subitem_supervisor": ""}]}]}, "item_1583105942107": {"attribute_name": "Authors", "attribute_value_mlt": [{"subitem_authors": [{"subitem_authors_fullname": "Gyi Aung"}, {"subitem_authors_fullname": "Francois Niyonsaba"}, {"subitem_authors_fullname": "Hiroko Ushio"}, {"subitem_authors_fullname": "Naoki Kajiwara"}, {"subitem_authors_fullname": "Hirohisa Saito"}, {"subitem_authors_fullname": "Shigaku Ikeda"}, {"subitem_authors_fullname": "Hideoki Ogawa"}, {"subitem_authors_fullname": "Ko Okumura"}]}]}, "item_1583108359239": {"attribute_name": "Upload type", "attribute_value_mlt": [{"interim": "Publication"}]}, "item_1583108428133": {"attribute_name": "Publication type", "attribute_value_mlt": [{"interim": "Journal article"}]}, "item_1583159729339": {"attribute_name": "Publication date", "attribute_value": "2011-10-10"}, "item_1583159847033": {"attribute_name": "Identifier", "attribute_value": "10.5281/zenodo.3478848"}, "item_title": "Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines", "item_type_id": "21", "owner": "1", "path": ["1596631591423"], "permalink_uri": "http://hdl.handle.net/20.500.12678/0000003140", "pubdate": {"attribute_name": "Deposited date", "attribute_value": "2019-10-10"}, "publish_date": "2019-10-10", "publish_status": "0", "recid": "3140", "relation": {}, "relation_version_is_last": true, "title": ["Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines"], "weko_shared_id": -1}