{"created":"2020-08-30T20:01:39.383010+00:00","id":3140,"links":{},"metadata":{"_buckets":{"deposit":"16b78398-01d9-430d-9f8f-2a3d29483ac5"},"_deposit":{"id":"3140","owners":[],"pid":{"revision_id":0,"type":"recid","value":"3140"},"status":"published"},"_oai":{"id":"oai:meral.edu.mm:recid/3140","sets":["1582963366982:1596631591423"]},"communities":["um1"],"item_1583103067471":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines","subitem_1551255648112":""}]},"item_1583103085720":{"attribute_name":"Description","attribute_value_mlt":[{"interim":"<p>Catestatin, a neuroendocrine peptide with effects on human autonomic&nbsp;function, has recently been found to be a cutaneous antimicrobial peptide.&nbsp;Human catestatin exhibits three single nucleotide polymorphisms: Gly364-&nbsp;Ser, Pro370Leu and Arg374Gln. Given reports indicating that antimicrobial&nbsp;peptides and neuropeptides induce mast cell activation, we postulated&nbsp;that catestatin might stimulate numerous functions of human mast cells,&nbsp;thereby participating in the regulation of skin inflammatory responses.&nbsp;Catestatin and its naturally occurring variants caused the human mast cell&nbsp;line LAD2 and peripheral blood-derived mast cells to migrate, degranulate&nbsp;and release leukotriene C4 and prostaglandins D2 and E2. Moreover,&nbsp;catestatins increased intracellular Ca2+ mobilization in mast cells, and&nbsp;induced the production of pro-inflammatory cytokines/chemokines such&nbsp;as granulocyte&ndash;macrophage colony-stimulating factor, monocyte chemotactic&nbsp;protein-1/CCL2, macrophage inflammatory protein-1a/CCL3 and<br>\nmacrophage inflammatory protein-1b/CCL4.</p>"}]},"item_1583103108160":{"attribute_name":"Keywords","attribute_value":[]},"item_1583103120197":{"attribute_name":"Files","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-10-10"}],"displaytype":"preview","filename":"Catestatin, a neuroendocrine antimicrobial peptide, induces human.pdf","filesize":[{"value":"602 Kb"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"url":"https://meral.edu.mm/record/3140/files/Catestatin, a neuroendocrine antimicrobial peptide, induces human.pdf"},"version_id":"69bb55d8-8f8c-4392-9ba6-0732d2bfd15f"}]},"item_1583103131163":{"attribute_name":"Journal articles","attribute_value_mlt":[{"subitem_issue":"","subitem_journal_title":"Immunology: The Journal of Cells, Molecular, Systems and Technologies","subitem_pages":"1-13","subitem_volume":""}]},"item_1583103147082":{"attribute_name":"Conference papers","attribute_value_mlt":[{"subitem_acronym":"","subitem_c_date":"","subitem_conference_title":"","subitem_part":"","subitem_place":"","subitem_session":"","subitem_website":""}]},"item_1583103211336":{"attribute_name":"Books/reports/chapters","attribute_value_mlt":[{"subitem_book_title":"","subitem_isbn":"","subitem_pages":"","subitem_place":"","subitem_publisher":""}]},"item_1583103233624":{"attribute_name":"Thesis/dissertations","attribute_value_mlt":[{"subitem_awarding_university":"","subitem_supervisor(s)":[{"subitem_supervisor":""}]}]},"item_1583105942107":{"attribute_name":"Authors","attribute_value_mlt":[{"subitem_authors":[{"subitem_authors_fullname":"Gyi Aung"},{"subitem_authors_fullname":"Francois Niyonsaba"},{"subitem_authors_fullname":"Hiroko Ushio"},{"subitem_authors_fullname":"Naoki Kajiwara"},{"subitem_authors_fullname":"Hirohisa Saito"},{"subitem_authors_fullname":"Shigaku Ikeda"},{"subitem_authors_fullname":"Hideoki Ogawa"},{"subitem_authors_fullname":"Ko Okumura"}]}]},"item_1583108359239":{"attribute_name":"Upload type","attribute_value_mlt":[{"interim":"Publication"}]},"item_1583108428133":{"attribute_name":"Publication type","attribute_value_mlt":[{"interim":"Journal article"}]},"item_1583159729339":{"attribute_name":"Publication date","attribute_value":"2011-10-10"},"item_1583159847033":{"attribute_name":"Identifier","attribute_value":"10.5281/zenodo.3478848"},"item_title":"Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines","item_type_id":"21","owner":"1","path":["1596631591423"],"publish_date":"2019-10-10","publish_status":"0","recid":"3140","relation_version_is_last":true,"title":["Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2021-12-13T05:47:41.397204+00:00"}