{"_buckets": {"deposit": "7653acbc-9d94-48fa-8b72-a307b60f4891"}, "_deposit": {"id": "3135", "owners": [], "pid": {"revision_id": 0, "type": "recid", "value": "3135"}, "status": "published"}, "_oai": {"id": "oai:meral.edu.mm:recid/3135", "sets": ["user-um1"]}, "communities": ["um1"], "item_1583103067471": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Differential effect of etretinate on proliferation and extracellular matrix metabolism of human dermal fibroblasts from elderly and young individuals in a novel three-dimensional culture", "subitem_1551255648112": ""}]}, "item_1583103085720": {"attribute_name": "Description", "attribute_value_mlt": [{"interim": "\u003cp\u003eThe effect of etretinate on proliferation and biosynthesiso f collagensa nd glycosaminoglycans(G AGS) were\u003cbr\u003e\ninvestigatedu sing human dermal fibroblasts in a novel three-dimensionacl ulture supplementedw ith L-ascorbica cid\u003cbr\u003e\n2-phosphate. Fibroblasts from two young and two elderly individuals were studied at different concentrations of\u003cbr\u003e\netretinate, 0.25, 1. O and 2.5 pg/ml. Collagens( hydroxyproline) and GAGS (disaccharideu nits) extracted from the cell\u003cbr\u003e\nlayer were analyzed and quantified biochemically by high-performance liquid chromatography (HPLC). Etretinate\u003cbr\u003e\nshowed no significant effect on fibroblast proliferation either in the monolayer or the three-dimensionacl ulture.\u003cbr\u003e\nEtretinate increasedth e collageno r GAGS content in the cell layer, which was prominent at etretinate concentrations\u003cbr\u003e\nof 1.0 and 2.5 or 0.25 pg/ml, respectivelyi n fibroblastsf rom the elderly (P \u0026lt; 0.05). This effect was not seenin dermal\u003cbr\u003e\nfibroblast from the young. Theser esultss uggesth at etretinate may have the differential effect on collagena nd GAG\u003cbr\u003e\nmetabolismsd ependingo n the donor age of the cultured fibroblasts.0 1998E lsevier ScienceI reland Ltd. All rights\u003cbr\u003e\nreserved.\u003c/p\u003e"}]}, "item_1583103108160": {"attribute_name": "Keywords", "attribute_value": []}, "item_1583103120197": {"attribute_name": "Files", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2019-08-23"}], "displaytype": "preview", "download_preview_message": "", "file_order": 0, "filename": "1-s2.0-S0923181198000358-main 2.pdf", "filesize": [{"value": "958 Kb"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_0", "mimetype": "application/pdf", "size": 958000.0, "url": {"url": "https://meral.edu.mm/record/3135/files/1-s2.0-S0923181198000358-main 2.pdf"}, "version_id": "dff644d7-5420-484f-b697-40cd2c2dc9b3"}]}, "item_1583103131163": {"attribute_name": "Journal articles", "attribute_value_mlt": [{"subitem_issue": "", "subitem_journal_title": "JOURNALOF Dermatological Science", "subitem_pages": "155-162", "subitem_volume": "18"}]}, "item_1583103147082": {"attribute_name": "Conference papers", "attribute_value_mlt": [{"subitem_acronym": "", "subitem_c_date": "", "subitem_conference_title": "", "subitem_part": "", "subitem_place": "", "subitem_session": "", "subitem_website": ""}]}, "item_1583103211336": {"attribute_name": "Books/reports/chapters", "attribute_value_mlt": [{"subitem_book_title": "", "subitem_isbn": "", "subitem_pages": "", "subitem_place": "", "subitem_publisher": ""}]}, "item_1583103233624": {"attribute_name": "Thesis/dissertations", "attribute_value_mlt": [{"subitem_awarding_university": "", "subitem_supervisor(s)": [{"subitem_supervisor": ""}]}]}, "item_1583105942107": {"attribute_name": "Authors", "attribute_value_mlt": [{"subitem_authors": [{"subitem_authors_fullname": "Khine Khine Zaw"}, {"subitem_authors_fullname": "Osamu Ishikawa"}, {"subitem_authors_fullname": "Yoshiki Miyachi"}]}]}, "item_1583108359239": {"attribute_name": "Upload type", "attribute_value_mlt": [{"interim": "Publication"}]}, "item_1583108428133": {"attribute_name": "Publication type", "attribute_value_mlt": [{"interim": "Journal article"}]}, "item_1583159729339": {"attribute_name": "Publication date", "attribute_value": "1998-09-15"}, "item_1583159847033": {"attribute_name": "Identifier", "attribute_value": "10.5281/zenodo.3375345"}, "item_title": "Differential effect of etretinate on proliferation and extracellular matrix metabolism of human dermal fibroblasts from elderly and young individuals in a novel three-dimensional culture", "item_type_id": "21", "owner": "1", "path": ["1596631591423"], "permalink_uri": "http://hdl.handle.net/20.500.12678/0000003135", "pubdate": {"attribute_name": "Deposited date", "attribute_value": "2019-08-23"}, "publish_date": "2019-08-23", "publish_status": "0", "recid": "3135", "relation": {}, "relation_version_is_last": true, "title": ["Differential effect of etretinate on proliferation and extracellular matrix metabolism of human dermal fibroblasts from elderly and young individuals in a novel three-dimensional culture"], "weko_shared_id": -1}