{"created":"2020-08-30T20:01:10.480439+00:00","id":3135,"links":{},"metadata":{"_buckets":{"deposit":"7653acbc-9d94-48fa-8b72-a307b60f4891"},"_deposit":{"id":"3135","owners":[],"pid":{"revision_id":0,"type":"recid","value":"3135"},"status":"published"},"_oai":{"id":"oai:meral.edu.mm:recid/3135","sets":["1582963366982:1596631591423"]},"communities":["um1"],"item_1583103067471":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Differential effect of etretinate on proliferation and extracellular matrix metabolism of human dermal fibroblasts from elderly and young individuals in a novel three-dimensional culture","subitem_1551255648112":""}]},"item_1583103085720":{"attribute_name":"Description","attribute_value_mlt":[{"interim":"<p>The effect of etretinate on proliferation and biosynthesiso f collagensa nd glycosaminoglycans(G AGS) were<br>\ninvestigatedu sing human dermal fibroblasts in a novel three-dimensionacl ulture supplementedw ith L-ascorbica cid<br>\n2-phosphate. Fibroblasts from two young and two elderly individuals were studied at different concentrations of<br>\netretinate, 0.25, 1. O and 2.5 pg/ml. Collagens( hydroxyproline) and GAGS (disaccharideu nits) extracted from the cell<br>\nlayer were analyzed and quantified biochemically by high-performance liquid chromatography (HPLC). Etretinate<br>\nshowed no significant effect on fibroblast proliferation either in the monolayer or the three-dimensionacl ulture.<br>\nEtretinate increasedth e collageno r GAGS content in the cell layer, which was prominent at etretinate concentrations<br>\nof 1.0 and 2.5 or 0.25 pg/ml, respectivelyi n fibroblastsf rom the elderly (P &lt; 0.05). This effect was not seenin dermal<br>\nfibroblast from the young. Theser esultss uggesth at etretinate may have the differential effect on collagena nd GAG<br>\nmetabolismsd ependingo n the donor age of the cultured fibroblasts.0 1998E lsevier ScienceI reland Ltd. All rights<br>\nreserved.</p>"}]},"item_1583103108160":{"attribute_name":"Keywords","attribute_value":[]},"item_1583103120197":{"attribute_name":"Files","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-08-23"}],"displaytype":"preview","filename":"1-s2.0-S0923181198000358-main 2.pdf","filesize":[{"value":"958 Kb"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"url":"https://meral.edu.mm/record/3135/files/1-s2.0-S0923181198000358-main 2.pdf"},"version_id":"dff644d7-5420-484f-b697-40cd2c2dc9b3"}]},"item_1583103131163":{"attribute_name":"Journal articles","attribute_value_mlt":[{"subitem_issue":"","subitem_journal_title":"JOURNALOF Dermatological Science","subitem_pages":"155-162","subitem_volume":"18"}]},"item_1583103147082":{"attribute_name":"Conference papers","attribute_value_mlt":[{"subitem_acronym":"","subitem_c_date":"","subitem_conference_title":"","subitem_part":"","subitem_place":"","subitem_session":"","subitem_website":""}]},"item_1583103211336":{"attribute_name":"Books/reports/chapters","attribute_value_mlt":[{"subitem_book_title":"","subitem_isbn":"","subitem_pages":"","subitem_place":"","subitem_publisher":""}]},"item_1583103233624":{"attribute_name":"Thesis/dissertations","attribute_value_mlt":[{"subitem_awarding_university":"","subitem_supervisor(s)":[{"subitem_supervisor":""}]}]},"item_1583105942107":{"attribute_name":"Authors","attribute_value_mlt":[{"subitem_authors":[{"subitem_authors_fullname":"Khine Khine Zaw"},{"subitem_authors_fullname":"Osamu Ishikawa"},{"subitem_authors_fullname":"Yoshiki Miyachi"}]}]},"item_1583108359239":{"attribute_name":"Upload type","attribute_value_mlt":[{"interim":"Publication"}]},"item_1583108428133":{"attribute_name":"Publication type","attribute_value_mlt":[{"interim":"Journal article"}]},"item_1583159729339":{"attribute_name":"Publication date","attribute_value":"1998-09-15"},"item_1583159847033":{"attribute_name":"Identifier","attribute_value":"10.5281/zenodo.3375345"},"item_title":"Differential effect of etretinate on proliferation and extracellular matrix metabolism of human dermal fibroblasts from elderly and young individuals in a novel three-dimensional culture","item_type_id":"21","owner":"1","path":["1596631591423"],"publish_date":"2019-08-23","publish_status":"0","recid":"3135","relation_version_is_last":true,"title":["Differential effect of etretinate on proliferation and extracellular matrix metabolism of human dermal fibroblasts from elderly and young individuals in a novel three-dimensional culture"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2021-12-13T05:48:05.207052+00:00"}