{"_buckets": {"deposit": "4c446707-e56f-4760-a8c2-1a4cc6541f25"}, "_deposit": {"id": "3128", "owners": [], "pid": {"revision_id": 0, "type": "recid", "value": "3128"}, "status": "published"}, "_oai": {"id": "oai:meral.edu.mm:recid/3128", "sets": ["user-um1"]}, "communities": ["um1"], "item_1583103067471": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Induction of acyl-coenzyme A:cholesterol acyltransferase-1 by 1,25-dihydroxyvitamin D 3 or 9- cis -retinoic acid in undifferentiated THP-1 cells", "subitem_1551255648112": ""}]}, "item_1583103085720": {"attribute_name": "Description", "attribute_value_mlt": [{"interim": "\u003cp\u003eAbstract We have previously shown that acyl-coenzyme A:\u0026nbsp;cholesterol acyltransferase-1 (ACAT-1) protein content increases\u003cbr\u003e\nsignificantly during the human monocyte-macrophage\u0026nbsp;differentiation process. To gain further insight, we\u0026nbsp;used undifferentiated human monocytic THP-1 cells as a\u0026nbsp;model system with which to examine whether ACAT-1\u0026nbsp;mRNA and protein content can be increased by treating\u0026nbsp;cells with 1,25-dihydroxyvitamin D\u0026nbsp;3\u0026nbsp;[1,25-(OH)\u0026nbsp;2D3] or with\u0026nbsp;9-cis\u0026nbsp;-retinoic acid (9-cis-RA), two agents known to upregulate\u003cbr\u003e\nthe expression of various genes during the monocyte-macrophage\u0026nbsp;differentiation process. Immunoblot analysis with\u0026nbsp;anti-human ACAT-1 antibodies revealed that ACAT-1 protein\u0026nbsp;was increased by 2.6-fold, using 1,25-(OH)\u0026nbsp;2D3\u0026nbsp;at a physiological\u0026nbsp;concentration (100 pM). ACAT-1 protein was also\u0026nbsp;increased when using 9-cis-RA, but only at relatively high\u0026nbsp;concentrations (0.1\u0026ndash;1M).\u003c/p\u003e"}]}, "item_1583103108160": {"attribute_name": "Keywords", "attribute_value": []}, "item_1583103120197": {"attribute_name": "Files", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2019-08-21"}], "displaytype": "preview", "download_preview_message": "", "file_order": 0, "filename": "Induction of acyl-coenzyme.pdf", "filesize": [{"value": "1219 Kb"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_0", "mimetype": "application/pdf", "size": 1219000.0, "url": {"url": "https://meral.edu.mm/record/3128/files/Induction of acyl-coenzyme.pdf"}, "version_id": "1ab670f8-2e55-4d43-bd8d-cb4859f0549f"}]}, "item_1583103131163": {"attribute_name": "Journal articles", "attribute_value_mlt": [{"subitem_issue": "", "subitem_journal_title": "Journal of Lipid Research", "subitem_pages": "181-188", "subitem_volume": "42"}]}, "item_1583103147082": {"attribute_name": "Conference papers", "attribute_value_mlt": [{"subitem_acronym": "", "subitem_c_date": "", "subitem_conference_title": "", "subitem_part": "", "subitem_place": "", "subitem_session": "", "subitem_website": ""}]}, "item_1583103211336": {"attribute_name": "Books/reports/chapters", "attribute_value_mlt": [{"subitem_book_title": "", "subitem_isbn": "", "subitem_pages": "", "subitem_place": "", "subitem_publisher": ""}]}, "item_1583103233624": {"attribute_name": "Thesis/dissertations", "attribute_value_mlt": [{"subitem_awarding_university": "", "subitem_supervisor(s)": [{"subitem_supervisor": ""}]}]}, "item_1583105942107": {"attribute_name": "Authors", "attribute_value_mlt": [{"subitem_authors": [{"subitem_authors_fullname": "Kyu Kyu Maung"}, {"subitem_authors_fullname": "Akira Miyazaki"}, {"subitem_authors_fullname": "Hisayuki Nomiyama"}, {"subitem_authors_fullname": "Catherine C. Y. Chang"}, {"subitem_authors_fullname": "Ta-Yuan Chang"}, {"subitem_authors_fullname": "Seikoh Horiuchi"}]}]}, "item_1583108359239": {"attribute_name": "Upload type", "attribute_value_mlt": [{"interim": "Publication"}]}, "item_1583108428133": {"attribute_name": "Publication type", "attribute_value_mlt": [{"interim": "Journal article"}]}, "item_1583159729339": {"attribute_name": "Publication date", "attribute_value": "2019-05-21"}, "item_1583159847033": {"attribute_name": "Identifier", "attribute_value": "10.5281/zenodo.3373317"}, "item_title": "Induction of acyl-coenzyme A:cholesterol acyltransferase-1 by 1,25-dihydroxyvitamin D 3 or 9- cis -retinoic acid in undifferentiated THP-1 cells", "item_type_id": "21", "owner": "1", "path": ["1597649530495"], "permalink_uri": "http://hdl.handle.net/20.500.12678/0000003128", "pubdate": {"attribute_name": "Deposited date", "attribute_value": "2019-08-21"}, "publish_date": "2019-08-21", "publish_status": "0", "recid": "3128", "relation": {}, "relation_version_is_last": true, "title": ["Induction of acyl-coenzyme A:cholesterol acyltransferase-1 by 1,25-dihydroxyvitamin D 3 or 9- cis -retinoic acid in undifferentiated THP-1 cells"], "weko_shared_id": -1}