{"created":"2020-08-30T20:00:35.027835+00:00","id":3128,"links":{},"metadata":{"_buckets":{"deposit":"4c446707-e56f-4760-a8c2-1a4cc6541f25"},"_deposit":{"id":"3128","owners":[],"pid":{"revision_id":0,"type":"recid","value":"3128"},"status":"published"},"_oai":{"id":"oai:meral.edu.mm:recid/3128","sets":["1582963366982:1597649530495"]},"communities":["um1"],"item_1583103067471":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Induction of acyl-coenzyme A:cholesterol acyltransferase-1 by 1,25-dihydroxyvitamin D 3 or 9- cis -retinoic acid in undifferentiated THP-1 cells","subitem_1551255648112":""}]},"item_1583103085720":{"attribute_name":"Description","attribute_value_mlt":[{"interim":"<p>Abstract We have previously shown that acyl-coenzyme A:&nbsp;cholesterol acyltransferase-1 (ACAT-1) protein content increases<br>\nsignificantly during the human monocyte-macrophage&nbsp;differentiation process. To gain further insight, we&nbsp;used undifferentiated human monocytic THP-1 cells as a&nbsp;model system with which to examine whether ACAT-1&nbsp;mRNA and protein content can be increased by treating&nbsp;cells with 1,25-dihydroxyvitamin D&nbsp;3&nbsp;[1,25-(OH)&nbsp;2D3] or with&nbsp;9-cis&nbsp;-retinoic acid (9-cis-RA), two agents known to upregulate<br>\nthe expression of various genes during the monocyte-macrophage&nbsp;differentiation process. Immunoblot analysis with&nbsp;anti-human ACAT-1 antibodies revealed that ACAT-1 protein&nbsp;was increased by 2.6-fold, using 1,25-(OH)&nbsp;2D3&nbsp;at a physiological&nbsp;concentration (100 pM). ACAT-1 protein was also&nbsp;increased when using 9-cis-RA, but only at relatively high&nbsp;concentrations (0.1&ndash;1M).</p>"}]},"item_1583103108160":{"attribute_name":"Keywords","attribute_value":[]},"item_1583103120197":{"attribute_name":"Files","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-08-21"}],"displaytype":"preview","filename":"Induction of acyl-coenzyme.pdf","filesize":[{"value":"1219 Kb"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"url":"https://meral.edu.mm/record/3128/files/Induction of acyl-coenzyme.pdf"},"version_id":"1ab670f8-2e55-4d43-bd8d-cb4859f0549f"}]},"item_1583103131163":{"attribute_name":"Journal articles","attribute_value_mlt":[{"subitem_issue":"","subitem_journal_title":"Journal of Lipid Research","subitem_pages":"181-188","subitem_volume":"42"}]},"item_1583103147082":{"attribute_name":"Conference papers","attribute_value_mlt":[{"subitem_acronym":"","subitem_c_date":"","subitem_conference_title":"","subitem_part":"","subitem_place":"","subitem_session":"","subitem_website":""}]},"item_1583103211336":{"attribute_name":"Books/reports/chapters","attribute_value_mlt":[{"subitem_book_title":"","subitem_isbn":"","subitem_pages":"","subitem_place":"","subitem_publisher":""}]},"item_1583103233624":{"attribute_name":"Thesis/dissertations","attribute_value_mlt":[{"subitem_awarding_university":"","subitem_supervisor(s)":[{"subitem_supervisor":""}]}]},"item_1583105942107":{"attribute_name":"Authors","attribute_value_mlt":[{"subitem_authors":[{"subitem_authors_fullname":"Kyu Kyu Maung"},{"subitem_authors_fullname":"Akira Miyazaki"},{"subitem_authors_fullname":"Hisayuki Nomiyama"},{"subitem_authors_fullname":"Catherine C. Y. Chang"},{"subitem_authors_fullname":"Ta-Yuan Chang"},{"subitem_authors_fullname":"Seikoh Horiuchi"}]}]},"item_1583108359239":{"attribute_name":"Upload type","attribute_value_mlt":[{"interim":"Publication"}]},"item_1583108428133":{"attribute_name":"Publication type","attribute_value_mlt":[{"interim":"Journal article"}]},"item_1583159729339":{"attribute_name":"Publication date","attribute_value":"2019-05-21"},"item_1583159847033":{"attribute_name":"Identifier","attribute_value":"10.5281/zenodo.3373317"},"item_title":"Induction of acyl-coenzyme A:cholesterol acyltransferase-1 by 1,25-dihydroxyvitamin D 3 or 9- cis -retinoic acid in undifferentiated THP-1 cells","item_type_id":"21","owner":"1","path":["1597649530495"],"publish_date":"2019-08-21","publish_status":"0","recid":"3128","relation_version_is_last":true,"title":["Induction of acyl-coenzyme A:cholesterol acyltransferase-1 by 1,25-dihydroxyvitamin D 3 or 9- cis -retinoic acid in undifferentiated THP-1 cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2021-12-13T05:47:47.334293+00:00"}