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The aim of the\u0026nbsp;study was to compare the serum epidermal growth factor receptor and\u0026nbsp;cyclooxygenase-2 levels between patients with non-small cell carcinoma of\u0026nbsp;lung and healthy controls. This study included 53 patients diagnosed as\u0026nbsp;NSCLC and 16 apparently healthy controls. In 53 patients, 3 patients were\u003cbr\u003e\ndiagnosed as adenocarcinoma and 50 patients were diagnosed as squamous\u0026nbsp;cell carcinoma (SCC) of lung. In both subjects, serum EGFR and COX-2\u0026nbsp;levels were determined by ELISA. The mean serum EGFR and COX-2\u0026nbsp;levels of NSCLC patients were significantly higher than those of healthy\u0026nbsp;controls (170.10\u0026plusmn;13.80 vs. 3.56\u0026plusmn;0.48 ng/ml) and (13.21\u0026plusmn;3.17 vs. 0.62\u0026plusmn;\u0026nbsp;0.15 ng/ml), respectively\u0026nbsp;(p\u0026lt;0.001 in both). Both the mean serum EGFR\u0026nbsp;and COX-2 levels of SCC patients (172.10\u0026plusmn;14.30 ng/ml and 13.60\u0026plusmn;3.34\u003cbr\u003e\nng/ml) were significantly higher than those of healthy controls (p\u0026lt;0.001 in\u0026nbsp;both).\u003c/p\u003e"}]}, "item_1583103108160": {"attribute_name": "Keywords", "attribute_value_mlt": [{"interim": "Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung and Normal"}]}, "item_1583103120197": {"attribute_name": "Files", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2019-08-21"}], "displaytype": "preview", "download_preview_message": "", "file_order": 0, "filename": "Comparison of Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2.pdf", "filesize": [{"value": "88 Kb"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_0", "mimetype": "application/pdf", "size": 88000.0, "url": {"url": "https://meral.edu.mm/record/3126/files/Comparison of Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2.pdf"}, "version_id": "6dff5551-bfc5-4b4c-8975-a52289b921a9"}]}, "item_1583103131163": {"attribute_name": "Journal articles", "attribute_value_mlt": [{"subitem_issue": "1", "subitem_journal_title": "Myanmar Health Sciences Research Journal", "subitem_pages": "11-15", "subitem_volume": "28"}]}, "item_1583103147082": {"attribute_name": "Conference papers", "attribute_value_mlt": [{"subitem_acronym": "", "subitem_c_date": "", "subitem_conference_title": "", "subitem_part": "", "subitem_place": "", "subitem_session": "", "subitem_website": ""}]}, "item_1583103211336": {"attribute_name": "Books/reports/chapters", "attribute_value_mlt": [{"subitem_book_title": "", "subitem_isbn": "", "subitem_pages": "", "subitem_place": "", "subitem_publisher": ""}]}, "item_1583103233624": {"attribute_name": "Thesis/dissertations", "attribute_value_mlt": [{"subitem_awarding_university": "", "subitem_supervisor(s)": [{"subitem_supervisor": ""}]}]}, "item_1583105942107": {"attribute_name": "Authors", "attribute_value_mlt": [{"subitem_authors": [{"subitem_authors_fullname": "Thuzar Kyin Aung"}, {"subitem_authors_fullname": "Htar Kyi Sunn"}, {"subitem_authors_fullname": "Theingi Myint"}]}]}, "item_1583108359239": {"attribute_name": "Upload type", "attribute_value_mlt": [{"interim": "Publication"}]}, "item_1583108428133": {"attribute_name": "Publication type", "attribute_value_mlt": [{"interim": "Journal article"}]}, "item_1583159729339": {"attribute_name": "Publication date", "attribute_value": "2016-04-01"}, "item_1583159847033": {"attribute_name": "Identifier", "attribute_value": "10.5281/zenodo.3373274"}, "item_title": "Comparison of Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung and Normal Subjects", "item_type_id": "21", "owner": "1", "path": ["1597649530495"], "permalink_uri": "http://hdl.handle.net/20.500.12678/0000003126", "pubdate": {"attribute_name": "Deposited date", "attribute_value": "2019-08-21"}, "publish_date": "2019-08-21", "publish_status": "0", "recid": "3126", "relation": {}, "relation_version_is_last": true, "title": ["Comparison of Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung and Normal Subjects"], "weko_shared_id": -1}
Comparison of Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung and Normal Subjects
http://hdl.handle.net/20.500.12678/0000003126
http://hdl.handle.net/20.500.12678/000000312686577b5a-5b5a-4285-ba7c-df8c194915c9
966f31a3-27d8-45a8-a23d-d66ee485e9cf
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Publication type | ||||||
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Journal article | ||||||
Upload type | ||||||
Publication | ||||||
Title | ||||||
Title | Comparison of Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung and Normal Subjects | |||||
Publication date | 2016-04-01 | |||||
Authors | ||||||
Thuzar Kyin Aung | ||||||
Htar Kyi Sunn | ||||||
Theingi Myint | ||||||
Description | ||||||
<p>Relation of inflammation and cancer can be proven in most of the studies. Epidermal growth factor receptor (EGFR) overexpression is one of the commonest causes of non-small cell carcinoma of lung cancer (NSCLC). Cyclooxygenase-2 (COX-2) enzyme and its products; prostaglandin, prostacyclin, thromboxane are involved in inflammation. The aim of the study was to compare the serum epidermal growth factor receptor and cyclooxygenase-2 levels between patients with non-small cell carcinoma of lung and healthy controls. This study included 53 patients diagnosed as NSCLC and 16 apparently healthy controls. In 53 patients, 3 patients were<br> diagnosed as adenocarcinoma and 50 patients were diagnosed as squamous cell carcinoma (SCC) of lung. In both subjects, serum EGFR and COX-2 levels were determined by ELISA. The mean serum EGFR and COX-2 levels of NSCLC patients were significantly higher than those of healthy controls (170.10±13.80 vs. 3.56±0.48 ng/ml) and (13.21±3.17 vs. 0.62± 0.15 ng/ml), respectively (p<0.001 in both). Both the mean serum EGFR and COX-2 levels of SCC patients (172.10±14.30 ng/ml and 13.60±3.34<br> ng/ml) were significantly higher than those of healthy controls (p<0.001 in both).</p> |
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Keywords | ||||||
Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung and Normal | ||||||
Identifier | 10.5281/zenodo.3373274 | |||||
Journal articles | ||||||
1 | ||||||
Myanmar Health Sciences Research Journal | ||||||
11-15 | ||||||
28 | ||||||
Conference papers | ||||||
Books/reports/chapters | ||||||
Thesis/dissertations |