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  1. University of Yangon
  2. Department of Chemistry

A new polyoxygenated cyclohexene and a new megastigmane glycoside from Uvaria grandiflora

http://hdl.handle.net/20.500.12678/0000002382
http://hdl.handle.net/20.500.12678/0000002382
980f0286-4be4-4087-9111-c6fbe40ddfc4
0b8cceb6-6829-4d69-a6f6-f180ec99665b
Publication type
Journal article
Upload type
Publication
Title
Title A new polyoxygenated cyclohexene and a new megastigmane glycoside from Uvaria grandiflora
Language en
Publication date 2015
Authors
Ho, Duc Viet
Kodama, Takeshi
Le, Hien Thi Bich
Phan, Kiem Van
Do, Thao Thi
Bui, Tai Huu
Le, Anh Tuan
Nwet Nwet Win
Imagawa, Hiroshi
Ito, Takuya
Morita, Hiroyuki
Nguyen, Hoai Thi
Description
A new polyoxygenated cyclohexene, (-)-3-O-debenzoylzeylenone (1), and a new megastigmane glycoside, grandionoside A (2), were isolated from the aerial parts of Uvaria grandiflora collected in Vietnam, together with ten known compounds including polyoxygenated cyclohexenes (3-6), a triterpenoid (7), an alkaloid (8), a long chain alcohol (9), hexenyl glycopyranoside (10), and saponins (11-12). Their chemical structures were elucidated by a combination of extensive NMR spectroscopy with X-ray crystallographic analysis for 1, and chemical conversion for 2. Compound 1 exhibited significant cytotoxicity against the LU-1 and SK-Mel-2 cell lines with IC50 values of 4.68 and 3.63 μM, respectively. Remarkably, the cytotoxicity of 12 against the LU-1, KB, Hep-G2, MKN-7, and SW-480 cell lines was comparable to that of ellipticine, the positive control, with IC50 values ranging from 1.24 to 1.60 μM.
Keywords
Cytotoxicity
Identifier http://uyr.uy.edu.mm/handle/123456789/128
Journal articles
Conference papaers
Books/reports/chapters
Thesis/dissertations
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