{"_buckets": {"deposit": "0b8cceb6-6829-4d69-a6f6-f180ec99665b"}, "_deposit": {"id": "2382", "owners": [], "pid": {"revision_id": 0, "type": "recid", "value": "2382"}, "status": "published"}, "_oai": {"id": "oai:meral.edu.mm:recid/2382", "sets": ["1582967633684", "user-uy"]}, "communities": ["ccm", "ccp", "kyauksetu", "ltc", "maas", "miit", "mlmu", "mmu", "mtlu", "mtu", "mub", "mude", "mufl", "pathein", "scu", "suoe", "tcu", "tgu", "tuh", "tum", "ucsm", "ucsmtla", "ucsmub", "ucspathein", "ucstaungoo", "ucsy", "udmm", "udmy", "uit", "um", "um1", "um2", "umkn", "umm", "uphy", "urj", "uvs", "uy", "yau", "ydbu", "ytu", "yude", "yueco", "yufl", "yuoe"], "control_number": "2382", "item_1583103067471": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "A new polyoxygenated cyclohexene and a new megastigmane glycoside from Uvaria grandiflora", "subitem_1551255648112": "en"}]}, "item_1583103085720": {"attribute_name": "Description", "attribute_value_mlt": [{"interim": "A new polyoxygenated cyclohexene, (-)-3-O-debenzoylzeylenone (1), and a new megastigmane glycoside, grandionoside A (2), were isolated from the aerial parts of Uvaria grandiflora collected in Vietnam, together with ten known compounds including polyoxygenated cyclohexenes (3-6), a triterpenoid (7), an alkaloid (8), a long chain alcohol (9), hexenyl glycopyranoside (10), and saponins (11-12). Their chemical structures were elucidated by a combination of extensive NMR spectroscopy with X-ray crystallographic analysis for 1, and chemical conversion for 2. Compound 1 exhibited significant cytotoxicity against the LU-1 and SK-Mel-2 cell lines with IC50 values of 4.68 and 3.63 μM, respectively. Remarkably, the cytotoxicity of 12 against the LU-1, KB, Hep-G2, MKN-7, and SW-480 cell lines was comparable to that of ellipticine, the positive control, with IC50 values ranging from 1.24 to 1.60 μM."}]}, "item_1583103108160": {"attribute_name": "Keywords", "attribute_value_mlt": [{"interim": "Cytotoxicity"}]}, "item_1583103131163": {"attribute_name": "Journal articles", "attribute_value_mlt": [{}]}, "item_1583103147082": {"attribute_name": "Conference papaers", "attribute_value_mlt": [{}]}, "item_1583103211336": {"attribute_name": "Books/reports/chapters", "attribute_value_mlt": [{}]}, "item_1583103233624": {"attribute_name": "Thesis/dissertations", "attribute_value_mlt": [{"subitem_supervisor(s)": []}]}, "item_1583105942107": {"attribute_name": "Authors", "attribute_value_mlt": [{"subitem_authors": [{"subitem_authors_fullname": "Ho, Duc Viet"}, {"subitem_authors_fullname": "Kodama, Takeshi"}, {"subitem_authors_fullname": "Le, Hien Thi Bich"}, {"subitem_authors_fullname": "Phan, Kiem Van"}, {"subitem_authors_fullname": "Do, Thao Thi"}, {"subitem_authors_fullname": "Bui, Tai Huu"}, {"subitem_authors_fullname": "Le, Anh Tuan"}, {"subitem_authors_fullname": "Nwet Nwet Win"}, {"subitem_authors_fullname": "Imagawa, Hiroshi"}, {"subitem_authors_fullname": "Ito, Takuya"}, {"subitem_authors_fullname": "Morita, Hiroyuki"}, {"subitem_authors_fullname": "Nguyen, Hoai Thi"}]}]}, "item_1583108359239": {"attribute_name": "Upload type", "attribute_value_mlt": [{"interim": "Publication"}]}, "item_1583108428133": {"attribute_name": "Publication type", "attribute_value_mlt": [{"interim": "Journal article"}]}, "item_1583159729339": {"attribute_name": "Publication date", "attribute_value": "2015"}, "item_1583159847033": {"attribute_name": "Identifier", "attribute_value": "http://uyr.uy.edu.mm/handle/123456789/128"}, "item_title": "A new polyoxygenated cyclohexene and a new megastigmane glycoside from Uvaria grandiflora", "item_type_id": "21", "owner": "1", "path": ["1582967633684"], "permalink_uri": "http://hdl.handle.net/20.500.12678/0000002382", "pubdate": {"attribute_name": "Deposited date", "attribute_value": "2020-03-05"}, "publish_date": "2020-03-05", "publish_status": "0", "recid": "2382", "relation": {}, "relation_version_is_last": true, "title": ["A new polyoxygenated cyclohexene and a new megastigmane glycoside from Uvaria grandiflora"], "weko_shared_id": -1}