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Cytotoxic Constituents of Soymida febrifuga from Myanmar
http://hdl.handle.net/20.500.12678/0000002343
http://hdl.handle.net/20.500.12678/00000023432987b470-704c-4c5d-be2f-0809527e4308
b63a1ef9-cf9c-493f-9298-86b340a379ea
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Cytotoxic Constituents of Soymida.pdf (177 Kb)
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Journal article | ||||||
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Publication | ||||||
Title | ||||||
Title | Cytotoxic Constituents of Soymida febrifuga from Myanmar | |||||
Language | en | |||||
Publication date | 2009 | |||||
Authors | ||||||
Awale, Suresh | ||||||
Miyamoto, Tatsuya | ||||||
Thein Zaw Linn | ||||||
Nwet Nwet Win | ||||||
Tezuka, Yasuhiro | ||||||
Esumi, Hiroyasu | ||||||
Kadota, Shigetoshi | ||||||
Description | ||||||
The 70% ethanol extract of Soymida febrifuga was found to kill PANC-1 human pancreatic cancer cells preferentially under nutrition-deprived conditions at a concentration of 10 microg/mL. Phytochemical investigation led to the isolation of 27 compounds including four new compounds [(3R)-6,4'-dihydroxy-8-methoxyhomoisoflavan (1), (2R)-7,4'-dihydroxy-5-methoxy-8-methylflavan (2), 7-hydroxy-6-methoxy-3-(4'-hydroxybenzyl)coumarin (3), and 6-hydroxy-7-methoxy-3-(4'-hydroxybenzyl)coumarin (4)]. 2',4'-Dihydroxychalcone (8) displayed the most potent preferential cytotoxicity (PC(50) 19.0 microM) against PANC-1 cells. In addition, the cytotoxic activity against colon 26-L5 carcinoma (colon 26-L5), B16-BL6 melanoma (B16-BL6), lung A549 adenocarcinoma (A549), cervix HeLa adenocarcinoma (HeLa), and HT-1080 fibrosarcoma (HT-1080) cell lines and their structure-activity relationship are discussed. The cytotoxic activity of 4'-hydroxy-3,5-dimethoxystilbene (6) against colon 26-L5 (IC(50) 2.96 microM) was found to be stronger than the positive control, doxorubicin, at IC(50) 3.12 microM. | ||||||
Identifier | http://uyr.uy.edu.mm/handle/123456789/127 | |||||
Journal articles | ||||||
Conference papaers | ||||||
Books/reports/chapters | ||||||
Thesis/dissertations |