{"created":"2020-03-08T23:34:04.925339+00:00","id":2343,"links":{},"metadata":{"_buckets":{"deposit":"b63a1ef9-cf9c-493f-9298-86b340a379ea"},"_deposit":{"id":"2343","owners":[],"pid":{"revision_id":0,"type":"recid","value":"2343"},"status":"published"},"_oai":{"id":"oai:meral.edu.mm:recid/2343","sets":["1582963390870:1582967633684"]},"communities":["ccm","ccp","kyauksetu","ltc","maas","miit","mlmu","mmu","mtlu","mtu","mub","mude","mufl","pathein","scu","suoe","tcu","tgu","tuh","tum","ucsm","ucsmtla","ucsmub","ucspathein","ucstaungoo","ucsy","udmm","udmy","uit","um","um1","um2","umkn","umm","uphy","urj","uvs","uy","yau","ydbu","ytu","yude","yueco","yufl","yuoe"],"control_number":"2343","item_1583103067471":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Cytotoxic Constituents of Soymida febrifuga from Myanmar","subitem_1551255648112":"en"}]},"item_1583103085720":{"attribute_name":"Description","attribute_value_mlt":[{"interim":"The 70% ethanol extract of Soymida febrifuga was found to kill PANC-1 human pancreatic cancer cells preferentially under nutrition-deprived conditions at a concentration of 10 microg/mL. Phytochemical investigation led to the isolation of 27 compounds including four new compounds [(3R)-6,4'-dihydroxy-8-methoxyhomoisoflavan (1), (2R)-7,4'-dihydroxy-5-methoxy-8-methylflavan (2), 7-hydroxy-6-methoxy-3-(4'-hydroxybenzyl)coumarin (3), and 6-hydroxy-7-methoxy-3-(4'-hydroxybenzyl)coumarin (4)]. 2',4'-Dihydroxychalcone (8) displayed the most potent preferential cytotoxicity (PC(50) 19.0 microM) against PANC-1 cells. In addition, the cytotoxic activity against colon 26-L5 carcinoma (colon 26-L5), B16-BL6 melanoma (B16-BL6), lung A549 adenocarcinoma (A549), cervix HeLa adenocarcinoma (HeLa), and HT-1080 fibrosarcoma (HT-1080) cell lines and their structure-activity relationship are discussed. The cytotoxic activity of 4'-hydroxy-3,5-dimethoxystilbene (6) against colon 26-L5 (IC(50) 2.96 microM) was found to be stronger than the positive control, doxorubicin, at IC(50) 3.12 microM."}]},"item_1583103108160":{"attribute_name":"Keywords"},"item_1583103120197":{"attribute_name":"Files","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-05-05"}],"displaytype":"preview","filename":"Cytotoxic Constituents of Soymida.pdf","filesize":[{"value":"177 Kb"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://meral.edu.mm/record/2343/files/Cytotoxic Constituents of Soymida.pdf"},"version_id":"a6db61fc-687f-494b-8781-171b81d1553b"}]},"item_1583103131163":{"attribute_name":"Journal articles","attribute_value_mlt":[{}]},"item_1583103147082":{"attribute_name":"Conference papaers","attribute_value_mlt":[{}]},"item_1583103211336":{"attribute_name":"Books/reports/chapters","attribute_value_mlt":[{}]},"item_1583103233624":{"attribute_name":"Thesis/dissertations","attribute_value_mlt":[{"subitem_supervisor(s)":[]}]},"item_1583105942107":{"attribute_name":"Authors","attribute_value_mlt":[{"subitem_authors":[{"subitem_authors_fullname":"Awale, Suresh"},{"subitem_authors_fullname":"Miyamoto, Tatsuya"},{"subitem_authors_fullname":"Thein Zaw Linn"},{"subitem_authors_fullname":"Nwet Nwet Win"},{"subitem_authors_fullname":"Tezuka, Yasuhiro"},{"subitem_authors_fullname":"Esumi, Hiroyasu"},{"subitem_authors_fullname":"Kadota, Shigetoshi"}]}]},"item_1583108359239":{"attribute_name":"Upload type","attribute_value_mlt":[{"interim":"Publication"}]},"item_1583108428133":{"attribute_name":"Publication type","attribute_value_mlt":[{"interim":"Journal article"}]},"item_1583159729339":{"attribute_name":"Publication date","attribute_value":"2009"},"item_1583159847033":{"attribute_name":"Identifier","attribute_value":"http://uyr.uy.edu.mm/handle/123456789/127"},"item_title":"Cytotoxic Constituents of Soymida febrifuga from Myanmar","item_type_id":"21","owner":"1","path":["1582967633684"],"publish_date":"2020-03-05","publish_status":"0","recid":"2343","relation_version_is_last":true,"title":["Cytotoxic Constituents of Soymida febrifuga from Myanmar"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2021-12-13T06:38:27.056731+00:00"}