{"_buckets": {"deposit": "d8dad8db-e806-4ef7-b6f3-e67106df9c69"}, "_deposit": {"id": "2142", "owners": [], "pid": {"revision_id": 0, "type": "recid", "value": "2142"}, "status": "published"}, "_oai": {"id": "oai:meral.edu.mm:recid/2142", "sets": ["user-uy"]}, "communities": ["ccm", "ccp", "kyauksetu", "ltc", "maas", "miit", "mlmu", "mmu", "mtlu", "mtu", "mub", "mude", "mufl", "pathein", "scu", "suoe", "tcu", "tgu", "tuh", "tum", "ucsm", "ucsmtla", "ucsmub", "ucspathein", "ucstaungoo", "ucsy", "udmm", "udmy", "uit", "um", "um1", "um2", "umkn", "umm", "uphy", "urj", "uvs", "uy", "yau", "ydbu", "ytu", "yude", "yueco", "yufl", "yuoe"], "control_number": "2142", "item_1583103067471": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activity", "subitem_1551255648112": "en"}]}, "item_1583103085720": {"attribute_name": "Description", "attribute_value_mlt": [{"interim": "Viral protein R (Vpr), an accessory gene of HIV-1, plays important roles in viral pathogenesis. Screening of\r Myanmar medicinal plants that are popular as primary treatments for HIV/AIDS and for HIV-related\r problems revealed the potent anti-Vpr activity of the CHCl3-soluble extract of Kaempferia pulchra rhizomes,\r in comparison with that of the positive control, damnacanthal. Fractionation of the active\r CHCl3-soluble extract led to the identification of 30 isopimarane diterpenoids, including kaempulchraols\r A–W (1–23). All isolates were assayed for anti-Vpr activity against TREx-HeLa-Vpr cells, in which Vpr\r expression is tightly regulated by tetracycline. Kaempulchraols B (2), D (4), G (7), Q (17), T (20), U\r (21), and W (23) exhibited potent anti-Vpr activity, at concentrations ranging from 1.56 to 6.25 lM.\r The structure–activity relationships of the active kaempulchraols suggested that the presence of a\r hydroxy group at C-14 in an isopimara-8(9),15-diene skeleton and the presence of an acetoxy group at\r C-1 or C-7 in an isopimara-8(14),15-diene skeleton are the critical factors for the inhibitory effects\r against TREx-HeLa-Vpr cells."}]}, "item_1583103108160": {"attribute_name": "Keywords", "attribute_value_mlt": [{"interim": "Kaempferia pulchra"}]}, "item_1583103131163": {"attribute_name": "Journal articles", "attribute_value_mlt": [{}]}, "item_1583103147082": {"attribute_name": "Conference papaers", "attribute_value_mlt": [{}]}, "item_1583103211336": {"attribute_name": "Books/reports/chapters", "attribute_value_mlt": [{}]}, "item_1583103233624": {"attribute_name": "Thesis/dissertations", "attribute_value_mlt": [{"subitem_supervisor(s)": []}]}, "item_1583105942107": {"attribute_name": "Authors", "attribute_value_mlt": [{"subitem_authors": [{"subitem_authors_fullname": "Nwet Nwet Win"}, {"subitem_authors_fullname": "Ito, Takuya"}, {"subitem_authors_fullname": "Matsui, Takashi"}, {"subitem_authors_fullname": "Aimaiti, Simayijiang"}, {"subitem_authors_fullname": "Kodama, Takeshi"}, {"subitem_authors_fullname": "Hla Ngwe"}, {"subitem_authors_fullname": "Okamoto, Yasuko"}, {"subitem_authors_fullname": "Tanaka, Masami"}, {"subitem_authors_fullname": "Asakawa, Yoshinori"}, {"subitem_authors_fullname": "Abe, Ikuro"}, {"subitem_authors_fullname": "Morita, Hiroyuki"}]}]}, "item_1583108359239": {"attribute_name": "Upload type", "attribute_value_mlt": [{"interim": "Publication"}]}, "item_1583108428133": {"attribute_name": "Publication type", "attribute_value_mlt": [{"interim": "Journal article"}]}, "item_1583159729339": {"attribute_name": "Publication date", "attribute_value": "2016"}, "item_1583159847033": {"attribute_name": "Identifier", "attribute_value": "http://uyr.uy.edu.mm/handle/123456789/124"}, "item_title": "Isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activity", "item_type_id": "21", "owner": "1", "path": ["1582967633684"], "permalink_uri": "http://hdl.handle.net/20.500.12678/0000002142", "pubdate": {"attribute_name": "Deposited date", "attribute_value": "2020-03-05"}, "publish_date": "2020-03-05", "publish_status": "0", "recid": "2142", "relation": {}, "relation_version_is_last": true, "title": ["Isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activity"], "weko_shared_id": -1}