{"created":"2020-03-08T23:27:19.451268+00:00","id":2142,"links":{},"metadata":{"_buckets":{"deposit":"d8dad8db-e806-4ef7-b6f3-e67106df9c69"},"_deposit":{"id":"2142","owners":[],"pid":{"revision_id":0,"type":"recid","value":"2142"},"status":"published"},"_oai":{"id":"oai:meral.edu.mm:recid/2142","sets":["1582963390870:1582967633684"]},"communities":["ccm","ccp","kyauksetu","ltc","maas","miit","mlmu","mmu","mtlu","mtu","mub","mude","mufl","pathein","scu","suoe","tcu","tgu","tuh","tum","ucsm","ucsmtla","ucsmub","ucspathein","ucstaungoo","ucsy","udmm","udmy","uit","um","um1","um2","umkn","umm","uphy","urj","uvs","uy","yau","ydbu","ytu","yude","yueco","yufl","yuoe"],"control_number":"2142","item_1583103067471":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activity","subitem_1551255648112":"en"}]},"item_1583103085720":{"attribute_name":"Description","attribute_value_mlt":[{"interim":"Viral protein R (Vpr), an accessory gene of HIV-1, plays important roles in viral pathogenesis. Screening of\r Myanmar medicinal plants that are popular as primary treatments for HIV/AIDS and for HIV-related\r problems revealed the potent anti-Vpr activity of the CHCl3-soluble extract of Kaempferia pulchra rhizomes,\r in comparison with that of the positive control, damnacanthal. Fractionation of the active\r CHCl3-soluble extract led to the identification of 30 isopimarane diterpenoids, including kaempulchraols\r A–W (1–23). All isolates were assayed for anti-Vpr activity against TREx-HeLa-Vpr cells, in which Vpr\r expression is tightly regulated by tetracycline. Kaempulchraols B (2), D (4), G (7), Q (17), T (20), U\r (21), and W (23) exhibited potent anti-Vpr activity, at concentrations ranging from 1.56 to 6.25 lM.\r The structure–activity relationships of the active kaempulchraols suggested that the presence of a\r hydroxy group at C-14 in an isopimara-8(9),15-diene skeleton and the presence of an acetoxy group at\r C-1 or C-7 in an isopimara-8(14),15-diene skeleton are the critical factors for the inhibitory effects\r against TREx-HeLa-Vpr cells."}]},"item_1583103108160":{"attribute_name":"Keywords","attribute_value_mlt":[{"interim":"Kaempferia pulchra"}]},"item_1583103131163":{"attribute_name":"Journal articles","attribute_value_mlt":[{}]},"item_1583103147082":{"attribute_name":"Conference papaers","attribute_value_mlt":[{}]},"item_1583103211336":{"attribute_name":"Books/reports/chapters","attribute_value_mlt":[{}]},"item_1583103233624":{"attribute_name":"Thesis/dissertations","attribute_value_mlt":[{"subitem_supervisor(s)":[]}]},"item_1583105942107":{"attribute_name":"Authors","attribute_value_mlt":[{"subitem_authors":[{"subitem_authors_fullname":"Nwet Nwet Win"},{"subitem_authors_fullname":"Ito, Takuya"},{"subitem_authors_fullname":"Matsui, Takashi"},{"subitem_authors_fullname":"Aimaiti, Simayijiang"},{"subitem_authors_fullname":"Kodama, Takeshi"},{"subitem_authors_fullname":"Hla Ngwe"},{"subitem_authors_fullname":"Okamoto, Yasuko"},{"subitem_authors_fullname":"Tanaka, Masami"},{"subitem_authors_fullname":"Asakawa, Yoshinori"},{"subitem_authors_fullname":"Abe, Ikuro"},{"subitem_authors_fullname":"Morita, Hiroyuki"}]}]},"item_1583108359239":{"attribute_name":"Upload type","attribute_value_mlt":[{"interim":"Publication"}]},"item_1583108428133":{"attribute_name":"Publication type","attribute_value_mlt":[{"interim":"Journal article"}]},"item_1583159729339":{"attribute_name":"Publication date","attribute_value":"2016"},"item_1583159847033":{"attribute_name":"Identifier","attribute_value":"http://uyr.uy.edu.mm/handle/123456789/124"},"item_title":"Isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activity","item_type_id":"21","owner":"1","path":["1582967633684"],"publish_date":"2020-03-05","publish_status":"0","recid":"2142","relation_version_is_last":true,"title":["Isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activity"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2021-12-13T03:48:59.110544+00:00"}