{"_buckets": {"deposit": "c4ba9562-981f-441f-b667-82694963745f"}, "_deposit": {"id": "1946", "owners": [], "pid": {"revision_id": 0, "type": "recid", "value": "1946"}, "status": "published"}, "_oai": {"id": "oai:meral.edu.mm:recid/1946", "sets": ["user-uy"]}, "communities": ["ccm", "ccp", "kyauksetu", "ltc", "maas", "miit", "mlmu", "mmu", "mtlu", "mtu", "mub", "mude", "mufl", "pathein", "scu", "suoe", "tcu", "tgu", "tuh", "tum", "ucsm", "ucsmtla", "ucsmub", "ucspathein", "ucstaungoo", "ucsy", "udmm", "udmy", "uit", "um", "um1", "um2", "umkn", "umm", "uphy", "urj", "uvs", "uy", "yau", "ydbu", "ytu", "yude", "yueco", "yufl", "yuoe"], "control_number": "1946", "item_1583103067471": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Preparation of Nanobetulinic Acid and Investigation of Some Bioactivities of Nanobetulinic Add and Betulinic Acid PerSe", "subitem_1551255648112": "en"}]}, "item_1583103085720": {"attribute_name": "Description", "attribute_value_mlt": [{"interim": "The aim of this project is to isolate the normal betulinic acid and prepare the nanobctulinic acid from the barks of Tectonahamiltoniana Wall (\u1012\u101f\u1010\u103a\u1021\u1001\u1031\u102b\u1000\u103a). Firstly, betulinic acid was detected in barks, leaves and flowers of Tectonahamiltoniana Wall. (Da-hat) plant grown in Pakokku Township (Magwe Region) by TLC and UV/Vis method. The highest amount of betulinic acid contain in barks. Normal betulinic acid was extracted with ethyl acetate solvent and recrystallized by ethanol to yield 1.66 %. Nanoparticles of betulinic acid were: prepared by wet-milling and dry-milling methods and the morphology and the size distribution of clusters of nanobetulinic acid were identified by SEM. It showed that the clusters of nanobetulinic acid produced by the dry-milling method were found to be powder form and in the range of 200-300 nm particle size. The chemical structure of normal betulinic acid and nanobetulinic acid were identified by FTIR and NMR modem techniques, As a result, the chemical structure of nanobetulinic acid was the same as that of normal betulinic acid. Unlike betulinic acid, nanobctulinic acid was found to be easily soluble in polar solvent ethanol. Antimicrobial activity showed that the growth of Bacillus subtilis. Bacillus pumilus, Candidaalbicansam Pseudomonas oeruginosa are significantly inhibited by nanobetulinic acid compared to normal betulinic acid and the negative control plates. Milling reduces the size and alters the size distribution of the drug particles. So nanobetulinic acids contribute to improved drug dissolution and solubility."}]}, "item_1583103108160": {"attribute_name": "Keywords", "attribute_value_mlt": [{"interim": "Tectonahamiltonianawall"}]}, "item_1583103120197": {"attribute_name": "Files", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2020-05-05"}], "displaytype": "preview", "download_preview_message": "", "file_order": 0, "filename": "Preparation of Nanobetulinic Acid and investigation of some Bioactivities of Nanobetulinic Acid and Betulinic Acid PerSe.pdf", "filesize": [{"value": "1864 Kb"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1864000.0, "url": {"url": "https://meral.edu.mm/record/1946/files/Preparation of Nanobetulinic Acid and investigation of some Bioactivities of Nanobetulinic Acid and Betulinic Acid PerSe.pdf"}, "version_id": "91e56f5d-0aae-4cbb-b4f2-bfbe3cf184a5"}]}, "item_1583103131163": {"attribute_name": "Journal articles", "attribute_value_mlt": [{"subitem_issue": "1 \u0026 2", "subitem_journal_title": "Journal of the Asia Research Centre", "subitem_volume": "5"}]}, "item_1583103147082": {"attribute_name": "Conference papaers", "attribute_value_mlt": [{}]}, "item_1583103211336": {"attribute_name": "Books/reports/chapters", "attribute_value_mlt": [{}]}, "item_1583103233624": {"attribute_name": "Thesis/dissertations", "attribute_value_mlt": [{"subitem_supervisor(s)": []}]}, "item_1583105942107": {"attribute_name": "Authors", "attribute_value_mlt": [{"subitem_authors": [{"subitem_authors_fullname": "Nan Thidar Chit Swe"}, {"subitem_authors_fullname": "Thida Min"}, {"subitem_authors_fullname": "Cho Cho"}, {"subitem_authors_fullname": "Khin Thein Soe"}, {"subitem_authors_fullname": "Wut Yee Aye"}, {"subitem_authors_fullname": "Nan Sandar Myint"}, {"subitem_authors_fullname": "Myo Aung"}, {"subitem_authors_fullname": "San Htoo"}, {"subitem_authors_fullname": "Aye Aye Myint"}, {"subitem_authors_fullname": "Myint Myint Khine"}]}]}, "item_1583108359239": {"attribute_name": "Upload type", "attribute_value_mlt": [{"interim": "Publication"}]}, "item_1583108428133": {"attribute_name": "Publication type", "attribute_value_mlt": [{"interim": "Journal article"}]}, "item_1583159729339": {"attribute_name": "Publication date", "attribute_value": "2016"}, "item_1583159847033": {"attribute_name": "Identifier", "attribute_value": "https://uyr.uy.edu.mm/handle/123456789/646"}, "item_title": "Preparation of Nanobetulinic Acid and Investigation of Some Bioactivities of Nanobetulinic Add and Betulinic Acid PerSe", "item_type_id": "21", "owner": "1", "path": ["1582967633684"], "permalink_uri": "http://hdl.handle.net/20.500.12678/0000001946", "pubdate": {"attribute_name": "Deposited date", "attribute_value": "2020-03-05"}, "publish_date": "2020-03-05", "publish_status": "0", "recid": "1946", "relation": {}, "relation_version_is_last": true, "title": ["Preparation of Nanobetulinic Acid and Investigation of Some Bioactivities of Nanobetulinic Add and Betulinic Acid PerSe"], "weko_shared_id": -1}