Log in
Language:

MERAL Myanmar Education Research and Learning Portal

  • Top
  • Universities
  • Ranking
To
lat lon distance
To

Field does not validate



Index Link

Index Tree

Please input email address.

WEKO

One fine body…

WEKO

One fine body…

Item

{"_buckets": {"deposit": "bb1e5129-127d-4a04-9cc5-e9b758901322"}, "_deposit": {"id": "891", "owners": [], "pid": {"revision_id": 0, "type": "recid", "value": "891"}, "status": "published"}, "_oai": {"id": "oai:meral.edu.mm:recid/891", "sets": ["user-um"]}, "communities": ["um"], "control_number": "891", "item_1583103067471": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Snake Venom Inhibition Activity of Rosmarinic acid from Argusia argentea", "subitem_1551255648112": "en"}]}, "item_1583103085720": {"attribute_name": "Description", "attribute_value_mlt": [{"interim": "A methanolic extract of Argusia argentea significantly inhibited\r hemorrhage induced by crude venom of Protobothrops flavoviridis\r (Habu). The extract was then separated according to antivenom activity\r by using silica gel column chromatography and HPLC equipped with an\r octadecylsilanized silica gel (ODS) column to afford rosmarinic acid\r (RA) (1) as an active principle. Anti-hemorrhagic activity was assayed by\r using several kinds of snake venom. RA (1) significally inhibited the\r hemorrhagic effect of crude venoms of P. flavoviridis, Crotalus atrox,\r Gloydius blomhoffii, Bitis arietans as well as purified snake venom\r metalloproteinases, HT-b (Crotalus atrox), bilitoxin-2 (Agkistrodon\r bilineatus), HT-1 (Bitis arietans) and Ac1-proteinase (Deinagkistrodon\r acutus). Inhibition against fibrinogen hydrolytic and collagen hydrolytic\r activities of P. flavoviridis venom were examined by SDS-PAGE. A\r histopathological study was done by microscopy after administration of\r venom in the presence or absence of RA (1). RA (1) was found to\r markedly neutralize venom-induced hemorrhage, fibrinogenolysis,\r cytotoxicity, lethality, edema and digestion of type IV collagen activity.\r Moreover, RA (1) inhibited both hemorrhage and neutrophil infiltrations\r caused by P. flavoviridis venom in pathology sections. These findings\r indicate that RA (1) can be expected to provide therapeutic benefits in\r neutralization of snake venom accompanied by heat stability."}]}, "item_1583103108160": {"attribute_name": "Keywords", "attribute_value_mlt": [{"interim": "Argusia argentea"}]}, "item_1583103120197": {"attribute_name": "Files", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2020-05-05"}], "displaytype": "preview", "download_preview_message": "", "file_order": 0, "filename": "Snake Venom Inhibition.pdf", "filesize": [{"value": "785 Kb"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 785000.0, "url": {"url": "https://meral.edu.mm/record/891/files/Snake Venom Inhibition.pdf"}, "version_id": "a13e6579-1e08-4c1e-a8ef-38596dac66d6"}]}, "item_1583103131163": {"attribute_name": "Journal articles", "attribute_value_mlt": [{"subitem_issue": "3", "subitem_journal_title": "Universities Research Journal", "subitem_volume": "4"}]}, "item_1583103147082": {"attribute_name": "Conference papaers", "attribute_value_mlt": [{}]}, "item_1583103211336": {"attribute_name": "Books/reports/chapters", "attribute_value_mlt": [{}]}, "item_1583103233624": {"attribute_name": "Thesis/dissertations", "attribute_value_mlt": [{"subitem_supervisor(s)": []}]}, "item_1583105942107": {"attribute_name": "Authors", "attribute_value_mlt": [{"subitem_authors": [{"subitem_authors_fullname": null}]}]}, "item_1583108359239": {"attribute_name": "Upload type", "attribute_value_mlt": [{"interim": "Other"}]}, "item_1583108428133": {"attribute_name": "Publication type", "attribute_value_mlt": [{"interim": "Report"}]}, "item_1583159729339": {"attribute_name": "Publication date", "attribute_value": "2011"}, "item_1583159847033": {"attribute_name": "Identifier", "attribute_value": "http://umoar.mu.edu.mm/handle/123456789/55"}, "item_title": "Snake Venom Inhibition Activity of Rosmarinic acid from Argusia argentea", "item_type_id": "21", "owner": "1", "path": ["1582967007954"], "permalink_uri": "http://hdl.handle.net/20.500.12678/0000000891", "pubdate": {"attribute_name": "Deposited date", "attribute_value": "2020-03-05"}, "publish_date": "2020-03-05", "publish_status": "0", "recid": "891", "relation": {}, "relation_version_is_last": true, "title": ["Snake Venom Inhibition Activity of Rosmarinic acid from Argusia argentea"], "weko_shared_id": -1}
  1. University of Mandalay
  2. Department of Chemistry

Snake Venom Inhibition Activity of Rosmarinic acid from Argusia argentea

http://hdl.handle.net/20.500.12678/0000000891
http://hdl.handle.net/20.500.12678/0000000891
6574e01f-9c8b-49bb-bb5c-624037ceedd8
bb1e5129-127d-4a04-9cc5-e9b758901322
None
Preview
Name / File License Actions
Snake Snake Venom Inhibition.pdf (785 Kb)
Publication type
Report
Upload type
Other
Title
Title Snake Venom Inhibition Activity of Rosmarinic acid from Argusia argentea
Language en
Publication date 2011
Authors
Description
A methanolic extract of Argusia argentea significantly inhibited
hemorrhage induced by crude venom of Protobothrops flavoviridis
(Habu). The extract was then separated according to antivenom activity
by using silica gel column chromatography and HPLC equipped with an
octadecylsilanized silica gel (ODS) column to afford rosmarinic acid
(RA) (1) as an active principle. Anti-hemorrhagic activity was assayed by
using several kinds of snake venom. RA (1) significally inhibited the
hemorrhagic effect of crude venoms of P. flavoviridis, Crotalus atrox,
Gloydius blomhoffii, Bitis arietans as well as purified snake venom
metalloproteinases, HT-b (Crotalus atrox), bilitoxin-2 (Agkistrodon
bilineatus), HT-1 (Bitis arietans) and Ac1-proteinase (Deinagkistrodon
acutus). Inhibition against fibrinogen hydrolytic and collagen hydrolytic
activities of P. flavoviridis venom were examined by SDS-PAGE. A
histopathological study was done by microscopy after administration of
venom in the presence or absence of RA (1). RA (1) was found to
markedly neutralize venom-induced hemorrhage, fibrinogenolysis,
cytotoxicity, lethality, edema and digestion of type IV collagen activity.
Moreover, RA (1) inhibited both hemorrhage and neutrophil infiltrations
caused by P. flavoviridis venom in pathology sections. These findings
indicate that RA (1) can be expected to provide therapeutic benefits in
neutralization of snake venom accompanied by heat stability.
Keywords
Argusia argentea
Identifier http://umoar.mu.edu.mm/handle/123456789/55
Journal articles
3
Universities Research Journal
4
Conference papaers
Books/reports/chapters
Thesis/dissertations
Back
0
0
views
downloads
See details
Views Downloads

Versions

Ver.1 2020-03-08 09:04:32.581675
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Export

OAI-PMH
  • OAI-PMH DublinCore
Other Formats
  • JSON

Confirm


Back to MERAL


Back to MERAL