Isolation and Structural Elucidation of an Unknown Bioactive Organic Compound from the Root of Litsea cubeba Pers.

Win Win Nwe, Dr; Aung Kyaw Moe; Thinn Myat Nwe, Dr; Myint Myint Sein, Dr

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Isolation and Structural Elucidation of an Unknown Bioactive Organic Compound from the Root of Litsea cubeba Pers.

http://hdl.handle.net/20.500.12678/0000007768

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Publication type
		Journal article
Upload type
		Publication
Title
	Title	Isolation and Structural Elucidation of an Unknown Bioactive Organic Compound from the Root of Litsea cubeba Pers.
	Language	en
Publication date		2021-01-25
Authors
		Win Win Nwe, Dr
		Aung Kyaw Moe
		Thinn Myat Nwe, Dr
		Myint Myint Sein, Dr
Description
		In this research work, preliminary phytochemical screening of one Myanmar indigenous medicinal plant, Litsea cubeba Pers. (Say-ta-lone) collected from Mogok, Mandalay Region was done. This test gives rise to positive for alkaloid, flavonoid, terpene, glycoside and polyphenol. Moreover, antimicrobial activities of crude extract of this compound were performed by agar well diffusion method. A pure bioactive organic compound was separated as yellow grains by modern separation methods such as thin layer and column chromatograms from the roots of Say-ta-lone. The yield percent is found to be (68 mg, 2.2 %) based upon the crude extract. The molecular formula of this compound was determined as C17H17NO5 using some sophisticated spectroscopic methods such as, FT-IR, 1H NMR (500 MHz), 13C NMR (125 MHz), HMQC, DEPT, DQF-COSY, HMBC and EI-mass spectrum respectively. Finally, this pure compound was tested for its MIC (Minimal Inhibitory Concentration) by microplate dilution method.
Keywords
		Phytochemical, antimicrobial, structural elucidation, thin layer chromatography, Fourier Transform Infrared
Journal articles
		I
		Meiktila University Research Journal,2020, Vol.XI, No.1
		225-230
		XI

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