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  1. University of Medicine 1
  2. Department of Pathology

Immunoexpression of Matrix Metalloproteinase-9 in Carcinoma Stomach

http://hdl.handle.net/20.500.12678/0000006963
http://hdl.handle.net/20.500.12678/0000006963
f8fe533a-575e-40ff-83c3-614f1a83df3d
efb3456c-2481-41cb-897a-a472e3d6e924
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10. 10. Dr.KZM.Patho. Final Edited.pdf (418 KB)
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Publication type
Journal article
Upload type
Publication
Title
Title Immunoexpression of Matrix Metalloproteinase-9 in Carcinoma Stomach
Language en
Publication date 2020-06-15
Authors
Kyaw Zin Myint
Saw Wut Hmone
Khin Thida Aung
Myint Myint Nyein
Myat Mon
Description
Carcinoma stomach is one of the most lethal cancers with high mortality and morbidity usually diagnosed in late stage. Prognosis of carcinoma stomach is determined by tumor invasion and metastasis so that the molecules participating in these steps become popular as potential prognostic markers. Matrix metalloproteinase-9 is a gelatinase B which breaks down the basement membrane and degrades the extracellular matrix resulting in tumor local invasion and metastasis. A cross-sectional descriptive study was done at Yangon General Hospital and University of Medicine 1 in which 37 gastrectomy specimens of gastric adenocarcinoma were included. MMP-9 immunoexpression and its association with different histological types and grades of carcinoma stomach were determined. The mean age in the carcinoma stomach was 60 ± 9.77 years with male: female ratio of 2.7:1. Out of 37 cases of gastric adenocarcinoma, 11% (4/37) were exophytic, 38% (14/37) were ulcerative, 19% (7/37) were ulceroinfiltrative and 32% (12/37) were diffuse infiltrative type. Histologically, 64.9% (24/37) were intestinal type and 35.1% (13/37) were diffuse type.
Keywords
Matrix Metalloproteinase-9, Carcinoma Stomach
Journal articles
2
Research Journal UM1
64-71
1
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