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  1. University of Medicine 1
  2. Department of Physiology

Impact of heart-specific disruption of the circadian clock on systemic glucose metabolism in mice

http://hdl.handle.net/20.500.12678/0000003198
http://hdl.handle.net/20.500.12678/0000003198
04701996-0bfd-418c-8d51-7df4d4955241
db79c1f1-5bf6-4bb8-84d7-6e91d2a9738f
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Impact Impact of heart-specific disruption of the circadian.pdf (1656 Kb)
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Publication type
Journal article
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Publication
Title
Title Impact of heart-specific disruption of the circadian clock on systemic glucose metabolism in mice
Publication date 2017-12-22
Authors
Tomomi Nakao
Akira Kohsaka
Tsuyoshi Otsuka
Zaw Lin Thein
Hue Thi Le
Hidefumi Waki
Sabine S Gouraud
Hayato Ihara
Masako Nakanishi
Fuyuki Sato
Yasuteru Muragaki
Masanobu Maeda
Description
<p>The daily rhythm of glucose metabolism is governed by the circadian clock, which consists of cellautonomous clock machineries residing in nearly every tissue in the body. Disruption of these clock machineries either environmentally or genetically induces the dysregulation of glucose metabolism. Although the roles of clock machineries in the regulation of glucose metabolism have been uncovered in major metabolic tissues, such as the pancreas, liver, and skeletal muscle, it remains unknown whether clock function in non-major metabolic tissues also affects systemic glucose metabolism. Here, we tested the hypothesis that disruption of the clock machinery in the heart might also affect systemic glucose metabolism, because heart function is known to be associated with glucose tolerance</p>
Keywords
Circadian clock, glucose metabolism, heart, liver
Identifier 10.5281/zenodo.3872814
Journal articles
Chronobiology International: The Journal of Biological and Medical Rhythm Research
1-12
Conference papers
Books/reports/chapters
Thesis/dissertations
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