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  1. University of Medicine 1
  2. Department of Physiology

Role of TLR4 in olfactory-based spatial learning activity of neonatal mice after developmental exposure to diesel exhaust origin secondary organic aerosol

http://hdl.handle.net/20.500.12678/0000003197
http://hdl.handle.net/20.500.12678/0000003197
1b770446-af0b-4c41-9e67-baf0e6716c6b
aa6135d3-d861-4ef2-8b60-fa1f79f5e64b
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02Role 02Role of TLR4 in olfactory-based spatial learning activity of neonatal mice after developmental exposure to diesel exhaustorigin secondary organic aerosol.pdf (1708 Kb)
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Journal article
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Publication
Title
Title Role of TLR4 in olfactory-based spatial learning activity of neonatal mice after developmental exposure to diesel exhaust origin secondary organic aerosol
Publication date 2017-06-02
Authors
Nay Chi Nway
Yuji Fujitani
Seishiro Hirano
Ohn Mar
Tin-Tin Win-Shwe
Description
<p>Exposure to ambient air pollutants has been reported to have various adverse health impacts. Ambient particulate matter comprises primary particles released directly via engine exhaust and secondary organic aerosols (SOAs) formed from oxidative reactions of the ultrafine particle fraction of diesel exhaust (DE). Toll-like receptor 4 (TLR4) is well known to initiate the inflammatory cascade in the central nervous system. However, whether and how DE and DE-SOA exposure influences TLR4 signaling in the immature<br>
brain remains unclear. We attempted to evaluate the roles of TLR-4, inflammatory mediators and microglial markers in the impaired spatial learning ability of neonatal mice exposed to DE and DE-SOAs. Pregnant C3H/HeN (TLR4-intact) and C3H/HeJ (TLR4- mutated) mice were exposed to clean air, DE or DESOA from gestational day 14 to postnatal day (PND) 10 (5 h/day for 5 days) in exposure chambers. PND11 neonatal mice were examined for their performance in the olfactory-based spatial learning test</p>
Keywords
Secondary organic aerosols, Toll-like receptor 4, Learning behavior, Neuroimmune markers, Neonate, Mice
Identifier 10.5281/zenodo.3872797
Journal articles
Role of TLR4 in olfactory-based spatial learning activity of neonatal mice after developmental exposure to diesel exhaust origin secondary organic aerosol
155-165
63
Conference papers
Books/reports/chapters
Thesis/dissertations
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