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It\u003cbr\u003e\nwas documented that S. japonicum species was prevalent in Shan State, Myanmar, but the serological study was\u003cbr\u003e\nnot conducted yet. General objective of the present study was to detect schistosoma antibodies and explore\u003cbr\u003e\nassociated factors among local residents living around Inlay Lake, Nyaung Shwe Township, and Southern Shan\u003cbr\u003e\nState, Myanmar.\u003cbr\u003e\nMethods: An exploratory and cross-sectional analytic study was conducted among local residents (n = 315) in\u003cbr\u003e\nselected rural health center (RHC) areas from December 2012 through June 2013. The participants were interviewed\u003cbr\u003e\nwith pretested semi-structured questionnaires and their blood samples (serum) were tested using Schistosomiasis\u003cbr\u003e\nSerology Microwell ELISA test kits (sensitivity 100% and specificity 85%) which detected IgG antibodies but could\u003cbr\u003e\nnot distinguish between a new and past infection. Data collected were analysed by SPSS software 16.0 and\u003cbr\u003e\nassociations of variables were determined by Chi-squared test with a significant level set at 0.05.\u003cbr\u003e\nResults: Schistosoma seroprevalence (IgG) in study area was found to be 23.8% (95% CI: 18.8\u0026ndash;28.8%). The present\u003cbr\u003e\nstudy is the first and foremost study producing serological evidence of schistosoma infection\u0026mdash;one of the\u003cbr\u003e\nneglected tropical diseases\u0026mdash;in local people of Myanmar. The factors significantly associated with seropositivity\u003cbr\u003e\nwere being male [OR = 2.6 (95% CI: 1.5\u0026ndash;4.49), P \u0026lt; 0.001], residence [OR = 3.41 (95% CI: 1.6-7.3), P \u0026lt; 0.05 for Khaung\u003cbr\u003e\nDaing vs. Min Chaung] and education levels [OR = 4.5 (95% CI: 1.18\u0026ndash;17.16),\u003cbr\u003e\nP \u0026lt; 0.05 for illiterate/3Rs level vs. high/graduate and OR = 3.16 (95% CI: 1.26\u0026ndash;7.93),\u003cbr\u003e\nP \u0026lt; 0.05 for primary/middle level vs. high/graduate] all factors classically associated with risk of schistosoma\u003cbr\u003e\ninfection. None of the behavioural factors tested were significantly associated with seropositivity.\u003cbr\u003e\nConclusion: Schistosoma infection serologically detected was most probably present at some time in this location\u003cbr\u003e\nof Myanmar, and this should be further confirmed parasitologically and kept under surveillance. Proper trainings on\u003cbr\u003e\ndiagnosis, treatment, prevention and control of schistosomiasis should be provided to the healthcare providers.\u003cbr\u003e\nTrial registration: ISRCTN ISRCTN73824458. Registered 28 September 2014, retrospectively registered.\u003c/p\u003e"}]}, "item_1583103108160": {"attribute_name": "Keywords", "attribute_value_mlt": [{"interim": "Schitosoma Antibodies and exploration of associated factors"}]}, "item_1583103120197": {"attribute_name": "Files", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2019-11-07"}], "displaytype": "preview", "download_preview_message": "", "file_order": 0, "filename": "8.Detection of Schistosoma Antibodies and.pdf", "filesize": [{"value": "388 Kb"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_0", "mimetype": "application/pdf", "size": 388000.0, "url": {"url": "https://meral.edu.mm/record/3149/files/8.Detection of Schistosoma Antibodies and.pdf"}, "version_id": "b70944f0-2833-4937-a0f5-d70a1134f9b2"}]}, "item_1583103131163": {"attribute_name": "Journal articles", "attribute_value_mlt": [{"subitem_issue": "3", "subitem_journal_title": "Infectious Diseases of Poverty", "subitem_pages": "1-6", "subitem_volume": "6"}]}, "item_1583103147082": {"attribute_name": "Conference papers", "attribute_value_mlt": [{"subitem_acronym": "", "subitem_c_date": "", "subitem_conference_title": "", "subitem_part": "", "subitem_place": "", "subitem_session": "", "subitem_website": ""}]}, "item_1583103211336": {"attribute_name": "Books/reports/chapters", "attribute_value_mlt": [{"subitem_book_title": "", "subitem_isbn": "", "subitem_pages": "", "subitem_place": "", "subitem_publisher": ""}]}, "item_1583103233624": {"attribute_name": "Thesis/dissertations", "attribute_value_mlt": [{"subitem_awarding_university": "", "subitem_supervisor(s)": [{"subitem_supervisor": ""}]}]}, "item_1583105942107": {"attribute_name": "Authors", "attribute_value_mlt": [{"subitem_authors": [{"subitem_authors_fullname": "Htin Zaw Soe"}, {"subitem_authors_fullname": "Cho Cho Oo"}, {"subitem_authors_fullname": "Tin Ohn Myat"}, {"subitem_authors_fullname": "Nay Soe Maung"}]}]}, "item_1583108359239": {"attribute_name": "Upload type", "attribute_value_mlt": [{"interim": "Publication"}]}, "item_1583108428133": {"attribute_name": "Publication type", "attribute_value_mlt": [{"interim": "Journal article"}]}, "item_1583159729339": {"attribute_name": "Publication date", "attribute_value": "2017-09-19"}, "item_1583159847033": {"attribute_name": "Identifier", "attribute_value": "10.5281/zenodo.3531193"}, "item_title": "Detection of Schistosoma Antibodies and exploration of associated factors among local residents around Inlay Lake, Southern Shan State, Myanmar", "item_type_id": "21", "owner": "1", "path": ["1596631680078"], "permalink_uri": "http://hdl.handle.net/20.500.12678/0000003149", "pubdate": {"attribute_name": "Deposited date", "attribute_value": "2019-11-07"}, "publish_date": "2019-11-07", "publish_status": "0", "recid": "3149", "relation": {}, "relation_version_is_last": true, "title": ["Detection of Schistosoma Antibodies and exploration of associated factors among local residents around Inlay Lake, Southern Shan State, Myanmar"], "weko_shared_id": -1}
  1. University of Medicine 1
  2. Department of Microbiology

Detection of Schistosoma Antibodies and exploration of associated factors among local residents around Inlay Lake, Southern Shan State, Myanmar

http://hdl.handle.net/20.500.12678/0000003149
http://hdl.handle.net/20.500.12678/0000003149
e9f78c78-5b92-45bd-a59f-598448eb3cb9
be97ed4d-b6c4-4234-bbdf-226d069adbe0
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Title
Title Detection of Schistosoma Antibodies and exploration of associated factors among local residents around Inlay Lake, Southern Shan State, Myanmar
Publication date 2017-09-19
Authors
Htin Zaw Soe
Cho Cho Oo
Tin Ohn Myat
Nay Soe Maung
Description
<p>Abstract<br>
Background: Schistosomiasis is a chronic parasitic disease caused by blood flukes (trematode worms) of the genus<br>
Schistosoma. Its transmission has been reported in 78 countries affecting at least 258 million people world-wide. It<br>
was documented that S. japonicum species was prevalent in Shan State, Myanmar, but the serological study was<br>
not conducted yet. General objective of the present study was to detect schistosoma antibodies and explore<br>
associated factors among local residents living around Inlay Lake, Nyaung Shwe Township, and Southern Shan<br>
State, Myanmar.<br>
Methods: An exploratory and cross-sectional analytic study was conducted among local residents (n = 315) in<br>
selected rural health center (RHC) areas from December 2012 through June 2013. The participants were interviewed<br>
with pretested semi-structured questionnaires and their blood samples (serum) were tested using Schistosomiasis<br>
Serology Microwell ELISA test kits (sensitivity 100% and specificity 85%) which detected IgG antibodies but could<br>
not distinguish between a new and past infection. Data collected were analysed by SPSS software 16.0 and<br>
associations of variables were determined by Chi-squared test with a significant level set at 0.05.<br>
Results: Schistosoma seroprevalence (IgG) in study area was found to be 23.8% (95% CI: 18.8&ndash;28.8%). The present<br>
study is the first and foremost study producing serological evidence of schistosoma infection&mdash;one of the<br>
neglected tropical diseases&mdash;in local people of Myanmar. The factors significantly associated with seropositivity<br>
were being male [OR = 2.6 (95% CI: 1.5&ndash;4.49), P &lt; 0.001], residence [OR = 3.41 (95% CI: 1.6-7.3), P &lt; 0.05 for Khaung<br>
Daing vs. Min Chaung] and education levels [OR = 4.5 (95% CI: 1.18&ndash;17.16),<br>
P &lt; 0.05 for illiterate/3Rs level vs. high/graduate and OR = 3.16 (95% CI: 1.26&ndash;7.93),<br>
P &lt; 0.05 for primary/middle level vs. high/graduate] all factors classically associated with risk of schistosoma<br>
infection. None of the behavioural factors tested were significantly associated with seropositivity.<br>
Conclusion: Schistosoma infection serologically detected was most probably present at some time in this location<br>
of Myanmar, and this should be further confirmed parasitologically and kept under surveillance. Proper trainings on<br>
diagnosis, treatment, prevention and control of schistosomiasis should be provided to the healthcare providers.<br>
Trial registration: ISRCTN ISRCTN73824458. Registered 28 September 2014, retrospectively registered.</p>
Keywords
Schitosoma Antibodies and exploration of associated factors
Identifier 10.5281/zenodo.3531193
Journal articles
3
Infectious Diseases of Poverty
1-6
6
Conference papers
Books/reports/chapters
Thesis/dissertations
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