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The aim of the study was to investigate the association between single nucleotide polymorphisms (SNP) at\u003cbr\u003e\nrs 1501299 (SNP+276 G\u0026gt;T) of the adiponectin gene and plasma adiponectin levels in type 2 diabetes mellitus (T2DM)\u003cbr\u003e\npatients in Myanmar.\u003cbr\u003e\nMethodology. One hundred T2DM patients and 104 non-diabetic subjects were included in this cross-sectional analytical\u003cbr\u003e\nstudy. Genotype frequencies were determined by polymerase chain reaction - restriction fragment length polymorphism\u003cbr\u003e\n(PCR-RFLP) method. Plasma adiponectin level was measured by enzyme-linked immunosorbent assay (ELISA).\u003cbr\u003e\nResult. Genotype frequencies (GG, GT, TT) of SNP+276 in diabetic patients were 39%, 48% and 13%, respectively. The\u003cbr\u003e\nGT and TT genotypes were more frequent in T2DM patients (OR 1.98, 95% CI, 1.10-3.55; p=0.02 and OR 4.07, 95%\u003cbr\u003e\nCI, 1.34-12.3; p=0.01), respectively. The T allele of SNP+276 was significantly associated with T2DM (OR 1.96, 95% CI,\u003cbr\u003e\n1.27-3.01; p=0.002). Mean plasma adiponectin level was significantly lower than in T2DM patients (27.41\u0026plusmn;16.7 \u0026mu;g/mL)\u003cbr\u003e\ncompared to non-diabetic subjects (37.19\u0026plusmn;26.77 \u0026mu;g/mL) (p=0.002).\u003cbr\u003e\nConclusion. SNP+276 at rs 1501299 of the adiponectin gene was associated with type 2 diabetes and low plasma\u003cbr\u003e\nadiponectin levels in this Myanmar population.\u003c/p\u003e"}]}, "item_1583103108160": {"attribute_name": "Keywords", "attribute_value_mlt": [{"interim": "adiponectin gene"}]}, "item_1583103120197": {"attribute_name": "Files", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2019-08-21"}], "displaytype": "preview", "download_preview_message": "", "file_order": 0, "filename": "Single Nucleotide Polymorphism at 276 G T of the Adiponectin Gene.pdf", "filesize": [{"value": "1048 Kb"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_0", "mimetype": "application/pdf", "size": 1048000.0, "url": {"url": "https://meral.edu.mm/record/3127/files/Single Nucleotide Polymorphism at 276 G T of the Adiponectin Gene.pdf"}, "version_id": "a52b1333-798d-4117-ad4b-719a4931547a"}]}, "item_1583103131163": {"attribute_name": "Journal articles", "attribute_value_mlt": [{"subitem_issue": "2", "subitem_journal_title": "Journal of the ASEAN Federation of Endocrine Societies", "subitem_pages": "160-164", "subitem_volume": "33"}]}, "item_1583103147082": {"attribute_name": "Conference papers", "attribute_value_mlt": [{"subitem_acronym": "", "subitem_c_date": "", "subitem_conference_title": "", "subitem_part": "", "subitem_place": "", "subitem_session": "", "subitem_website": ""}]}, "item_1583103211336": {"attribute_name": "Books/reports/chapters", "attribute_value_mlt": [{"subitem_book_title": "", "subitem_isbn": "", "subitem_pages": "", "subitem_place": "", "subitem_publisher": ""}]}, "item_1583103233624": {"attribute_name": "Thesis/dissertations", "attribute_value_mlt": [{"subitem_awarding_university": "", "subitem_supervisor(s)": [{"subitem_supervisor": ""}]}]}, "item_1583105942107": {"attribute_name": "Authors", "attribute_value_mlt": [{"subitem_authors": [{"subitem_authors_fullname": "Khin Thin Yu"}, {"subitem_authors_fullname": "Kyu Kyu Maung"}, {"subitem_authors_fullname": "Aye Thida"}, {"subitem_authors_fullname": "Thein Myint"}]}]}, "item_1583108359239": {"attribute_name": "Upload type", "attribute_value_mlt": [{"interim": "Publication"}]}, "item_1583108428133": {"attribute_name": "Publication type", "attribute_value_mlt": [{"interim": "Journal article"}]}, "item_1583159729339": {"attribute_name": "Publication date", "attribute_value": "2018-11-28"}, "item_1583159847033": {"attribute_name": "Identifier", "attribute_value": "10.5281/zenodo.3373308"}, "item_title": "Single Nucleotide Polymorphism at +276 G\u003eT of the Adiponectin Gene and Plasma Adiponectin Level in Myanmar Type 2 Diabetic Patients", "item_type_id": "21", "owner": "1", "path": ["1597649530495"], "permalink_uri": "http://hdl.handle.net/20.500.12678/0000003127", "pubdate": {"attribute_name": "Deposited date", "attribute_value": "2019-08-21"}, "publish_date": "2019-08-21", "publish_status": "0", "recid": "3127", "relation": {}, "relation_version_is_last": true, "title": ["Single Nucleotide Polymorphism at +276 G\u003eT of the Adiponectin Gene and Plasma Adiponectin Level in Myanmar Type 2 Diabetic Patients"], "weko_shared_id": -1}
Single Nucleotide Polymorphism at +276 G>T of the Adiponectin Gene and Plasma Adiponectin Level in Myanmar Type 2 Diabetic Patients
http://hdl.handle.net/20.500.12678/0000003127
http://hdl.handle.net/20.500.12678/0000003127204850f5-80c4-4aff-a742-0fc17701914f
b62bae2f-7dd7-4547-9104-9b0663eca910
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Journal article | ||||||
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Title | ||||||
Title | Single Nucleotide Polymorphism at +276 G>T of the Adiponectin Gene and Plasma Adiponectin Level in Myanmar Type 2 Diabetic Patients | |||||
Publication date | 2018-11-28 | |||||
Authors | ||||||
Khin Thin Yu | ||||||
Kyu Kyu Maung | ||||||
Aye Thida | ||||||
Thein Myint | ||||||
Description | ||||||
<p>Abstract<br> Objective. The aim of the study was to investigate the association between single nucleotide polymorphisms (SNP) at<br> rs 1501299 (SNP+276 G>T) of the adiponectin gene and plasma adiponectin levels in type 2 diabetes mellitus (T2DM)<br> patients in Myanmar.<br> Methodology. One hundred T2DM patients and 104 non-diabetic subjects were included in this cross-sectional analytical<br> study. Genotype frequencies were determined by polymerase chain reaction - restriction fragment length polymorphism<br> (PCR-RFLP) method. Plasma adiponectin level was measured by enzyme-linked immunosorbent assay (ELISA).<br> Result. Genotype frequencies (GG, GT, TT) of SNP+276 in diabetic patients were 39%, 48% and 13%, respectively. The<br> GT and TT genotypes were more frequent in T2DM patients (OR 1.98, 95% CI, 1.10-3.55; p=0.02 and OR 4.07, 95%<br> CI, 1.34-12.3; p=0.01), respectively. The T allele of SNP+276 was significantly associated with T2DM (OR 1.96, 95% CI,<br> 1.27-3.01; p=0.002). Mean plasma adiponectin level was significantly lower than in T2DM patients (27.41±16.7 μg/mL)<br> compared to non-diabetic subjects (37.19±26.77 μg/mL) (p=0.002).<br> Conclusion. SNP+276 at rs 1501299 of the adiponectin gene was associated with type 2 diabetes and low plasma<br> adiponectin levels in this Myanmar population.</p> |
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Keywords | ||||||
adiponectin gene | ||||||
Identifier | 10.5281/zenodo.3373308 | |||||
Journal articles | ||||||
2 | ||||||
Journal of the ASEAN Federation of Endocrine Societies | ||||||
160-164 | ||||||
33 | ||||||
Conference papers | ||||||
Books/reports/chapters | ||||||
Thesis/dissertations |