MERAL Myanmar Education Research and Learning Portal
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Association between HLA-B* 15:02 and carbamazepine induced severe cutaneous adverse drug reactions in Myanmar
http://hdl.handle.net/20.500.12678/0000003029
http://hdl.handle.net/20.500.12678/00000030297d934eab-79a7-4e75-a348-e36abf8b7978
0d7f0c87-5e4f-4e35-bd80-1f9d9826bb35
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Association between HLA-B 15.pdf (119 Kb)
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Publication type | ||||||
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Journal article | ||||||
Upload type | ||||||
Publication | ||||||
Title | ||||||
Title | Association between HLA-B* 15:02 and carbamazepine induced severe cutaneous adverse drug reactions in Myanmar | |||||
Language | en | |||||
Publication date | 2017-12-15 | |||||
Authors | ||||||
Amy Hui-Ping Khor | ||||||
Seinn Mya Mya Aye | ||||||
Kheng-Seang Lim | ||||||
Yan Lynn Aung | ||||||
Yin Minn Aye | ||||||
Ohnmar | ||||||
Win Min Thit | ||||||
Chong-Tin Tan | ||||||
Ching-Ching Ng | ||||||
Description | ||||||
Genetic predisposition to carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) had been reported in several Southeast Asian populations, but not in Myanmar. Previous studies had so far reported more than 70% of CBZ-induced SJS/TEN cases positive for HLA-B*15:02 allele.1-4 Myanmar, as the second largest country in Southeast Asia with a population of 54.5 million, has high HLA-B*15:02 carrier frequency in its general population (27.3- 49.1%).5,6. |
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Keywords | ||||||
Stevens-Johnson syndrome, Toxic epidermal necrolysis, Carbamazepine, HLA-B*15:02, Myanmar | ||||||
Journal articles | ||||||
3 | ||||||
Neurology Asia | ||||||
283-285 | ||||||
22 |