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  1. University of Medicine 1
  1. University of Medicine 1
  2. Department of Neurology

Association between HLA-B* 15:02 and carbamazepine induced severe cutaneous adverse drug reactions in Myanmar

http://hdl.handle.net/20.500.12678/0000003029
http://hdl.handle.net/20.500.12678/0000003029
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0d7f0c87-5e4f-4e35-bd80-1f9d9826bb35
Name / File License Actions
Association Association between HLA-B 15.pdf (119 Kb)
Publication type
Journal article
Upload type
Publication
Title
Title Association between HLA-B* 15:02 and carbamazepine induced severe cutaneous adverse drug reactions in Myanmar
Language en
Publication date 2017-12-15
Authors
Amy Hui-Ping Khor
Seinn Mya Mya Aye
Kheng-Seang Lim
Yan Lynn Aung
Yin Minn Aye
Ohnmar
Win Min Thit
Chong-Tin Tan
Ching-Ching Ng
Description
Genetic predisposition to carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) had been reported in several Southeast Asian populations, but not in Myanmar. Previous studies had so far reported more than 70% of CBZ-induced SJS/TEN cases
positive for HLA-B*15:02 allele.1-4 Myanmar, as the second largest country in Southeast Asia with a population of 54.5 million, has high HLA-B*15:02 carrier frequency in its general population (27.3- 49.1%).5,6.
Keywords
Stevens-Johnson syndrome, Toxic epidermal necrolysis, Carbamazepine, HLA-B*15:02, Myanmar
Journal articles
3
Neurology Asia
283-285
22
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