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Item

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Novel anticancer agents, kayeassamins C I from the flower of Kayea assamica of Myanmar

http://hdl.handle.net/20.500.12678/0000002710
52c0dbba-db67-4c93-97ef-c9602c831b4b
375bf3b4-01f3-47f4-9c79-a056041d3deb
Publication type
Journal article
Upload type
Publication
Title
Title Novel anticancer agents, kayeassamins C I from the flower of Kayea assamica of Myanmar
Language en
Publication date 2008
Authors
Nwet Nwet Win
Awale, Suresh
Esumi, Hiroyasu
Tezuka, Yasuhiro
Kadota, Shigetoshi
Description
A CHCl3-soluble fraction of 70% EtOH extract of the flower of Kayea assamica from Myanmar exhibited 100%
preferential cytotoxicity (PC100) against human pancreatic cancer PANC-1 cells under nutrient-deprived
conditions at 1 lg/mL. Bioassay-guided fractionation and isolation afforded nine new coumarins, kayeassamins
A (8), B (9), and CI (17), together with nine known coumarins (1018). The structures of these compounds
were identified by extensive spectroscopic techniques as well as by comparison with published
data. Absolute configuration at C-10 of 1 was established as S-configuration by the modifiedMosher method.
All the isolates were evaluated for their in vitro preferential cytotoxicity using novel anti-austerity strategy.
Among them, the novel coumarins, kayeassamins A (8), B (9), D (2), E (3), and G (5) exhibited the most potent
preferential cytotoxicity (PC100 1 lM) in a concentration- and time- dependent manner and induced apoptosis-like
morphological changes of PANC-1 cells within 24 h of treatment. Based on the observed cytotoxicity,
structure-activity relationships have been established.
Keywords
Anti-austerity strategy
Identifier http://uyr.uy.edu.mm/handle/123456789/116
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