Log in
Language:

MERAL Myanmar Education Research and Learning Portal

  • Top
  • Universities
  • Ranking
To
lat lon distance
To

Field does not validate



Index Link

Index Tree

Please input email address.

WEKO

One fine body…

WEKO

One fine body…

Item

{"_buckets": {"deposit": "2037828f-b089-4fce-82d5-23a663fd9186"}, "_deposit": {"id": "2569", "owners": [], "pid": {"revision_id": 0, "type": "recid", "value": "2569"}, "status": "published"}, "_oai": {"id": "oai:meral.edu.mm:recid/2569", "sets": ["user-uy"]}, "communities": ["ccm", "ccp", "kyauksetu", "ltc", "maas", "miit", "mlmu", "mmu", "mtlu", "mtu", "mub", "mude", "mufl", "pathein", "scu", "suoe", "tcu", "tgu", "tuh", "tum", "ucsm", "ucsmtla", "ucsmub", "ucspathein", "ucstaungoo", "ucsy", "udmm", "udmy", "uit", "um", "um1", "um2", "umkn", "umm", "uphy", "urj", "uvs", "uy", "yau", "ydbu", "ytu", "yude", "yueco", "yufl", "yuoe"], "control_number": "2569", "item_1583103067471": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum", "subitem_1551255648112": "en"}]}, "item_1583103085720": {"attribute_name": "Description", "attribute_value_mlt": [{"interim": "Aim of the study: For identification of the active constituents we investigated the anticancer activity of\r cardenolides from Streptocaulon tomentosum Wight \u0026 Arn. (Asclepiadaceae) and from Nerium oleander L.\r (Apocynaceae) which are both used against cancer in the traditional medicine in their region of origin.\r Material, methods and results: The antiproliferative activity of cardenolides isolated from roots of Streptocaulon\r tomentosum (IC50 \u003c 1–15.3 M after 2 days in MCF7) and of cardenolide containing fractions from\r the cold aqueous extract of Nerium oleander leaves (“Breastin”, mean IC50 0.85 g/ml in a panel of 36\r human tumor cell lines), their influence on the cellular viability and on the cell cycle (block at the G2/Mphase\r or at the S-phase in tumor cells, respectively) were determined using different cell lines. The murine\r cell line L929 and normal non-tumor cells were not affected. Bioactivity guided fractionation of Breastin\r resulted in the isolation of the monoglycosidic cardenolides oleandrine, oleandrigeninsarmentoside,\r neritaloside, odoroside H, and odoroside A (IC50-values between 0.010 and 0.071 g/ml).\r Conclusions: The observed anticancer activities of extracts and isolated cardenolides are in agreement with\r the ethnomedicinal use of Streptocaulon tomentosum and Nerium oleander. The most active anticancer\r compounds from both species are monoglycosidic cardenolides possessing the 3ˇ,14ˇ-dihydroxy-5ˇ-\r card-20(22)-enolide structure with or without an acetoxy group at C-16. The results indicate that the\r cytotoxic effects are induced by the inhibition of the plasma membrane bound Na+/K+-ATPase."}]}, "item_1583103108160": {"attribute_name": "Keywords", "attribute_value_mlt": [{"interim": "Cardenolides"}]}, "item_1583103131163": {"attribute_name": "Journal articles", "attribute_value_mlt": [{"subitem_journal_title": "Journal of Ethnopharmacology"}]}, "item_1583103147082": {"attribute_name": "Conference papaers", "attribute_value_mlt": [{}]}, "item_1583103211336": {"attribute_name": "Books/reports/chapters", "attribute_value_mlt": [{}]}, "item_1583103233624": {"attribute_name": "Thesis/dissertations", "attribute_value_mlt": [{"subitem_supervisor(s)": []}]}, "item_1583105942107": {"attribute_name": "Authors", "attribute_value_mlt": [{"subitem_authors": [{"subitem_authors_fullname": "Rashan, Luay J."}, {"subitem_authors_fullname": "Franke, Katrin"}, {"subitem_authors_fullname": "Myint Myint Khine"}, {"subitem_authors_fullname": "Kelter, Gerhard"}, {"subitem_authors_fullname": "Fiebig, Heinz H."}, {"subitem_authors_fullname": "Neumann, Joachim"}, {"subitem_authors_fullname": "Wessjohann, Ludger A."}]}]}, "item_1583108359239": {"attribute_name": "Upload type", "attribute_value_mlt": [{"interim": "Publication"}]}, "item_1583108428133": {"attribute_name": "Publication type", "attribute_value_mlt": [{"interim": "Journal article"}]}, "item_1583159729339": {"attribute_name": "Publication date", "attribute_value": "2011"}, "item_1583159847033": {"attribute_name": "Identifier", "attribute_value": "http://uyr.uy.edu.mm/handle/123456789/134"}, "item_title": "Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum", "item_type_id": "21", "owner": "1", "path": ["1582967633684"], "permalink_uri": "http://hdl.handle.net/20.500.12678/0000002569", "pubdate": {"attribute_name": "Deposited date", "attribute_value": "2020-03-05"}, "publish_date": "2020-03-05", "publish_status": "0", "recid": "2569", "relation": {}, "relation_version_is_last": true, "title": ["Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum"], "weko_shared_id": -1}
  1. University of Yangon
  2. Department of Chemistry

Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum

http://hdl.handle.net/20.500.12678/0000002569
http://hdl.handle.net/20.500.12678/0000002569
90d85699-2d01-4e2f-98c1-df8e932b6be7
2037828f-b089-4fce-82d5-23a663fd9186
Publication type
Journal article
Upload type
Publication
Title
Title Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum
Language en
Publication date 2011
Authors
Rashan, Luay J.
Franke, Katrin
Myint Myint Khine
Kelter, Gerhard
Fiebig, Heinz H.
Neumann, Joachim
Wessjohann, Ludger A.
Description
Aim of the study: For identification of the active constituents we investigated the anticancer activity of
cardenolides from Streptocaulon tomentosum Wight & Arn. (Asclepiadaceae) and from Nerium oleander L.
(Apocynaceae) which are both used against cancer in the traditional medicine in their region of origin.
Material, methods and results: The antiproliferative activity of cardenolides isolated from roots of Streptocaulon
tomentosum (IC50 < 1–15.3 M after 2 days in MCF7) and of cardenolide containing fractions from
the cold aqueous extract of Nerium oleander leaves (“Breastin”, mean IC50 0.85 g/ml in a panel of 36
human tumor cell lines), their influence on the cellular viability and on the cell cycle (block at the G2/Mphase
or at the S-phase in tumor cells, respectively) were determined using different cell lines. The murine
cell line L929 and normal non-tumor cells were not affected. Bioactivity guided fractionation of Breastin
resulted in the isolation of the monoglycosidic cardenolides oleandrine, oleandrigeninsarmentoside,
neritaloside, odoroside H, and odoroside A (IC50-values between 0.010 and 0.071 g/ml).
Conclusions: The observed anticancer activities of extracts and isolated cardenolides are in agreement with
the ethnomedicinal use of Streptocaulon tomentosum and Nerium oleander. The most active anticancer
compounds from both species are monoglycosidic cardenolides possessing the 3ˇ,14ˇ-dihydroxy-5ˇ-
card-20(22)-enolide structure with or without an acetoxy group at C-16. The results indicate that the
cytotoxic effects are induced by the inhibition of the plasma membrane bound Na+/K+-ATPase.
Keywords
Cardenolides
Identifier http://uyr.uy.edu.mm/handle/123456789/134
Journal articles
Journal of Ethnopharmacology
Conference papaers
Books/reports/chapters
Thesis/dissertations
Back
0
0
views
downloads
See details
Views Downloads

Versions

Ver.1 2020-03-08 23:42:39.019966
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Export

OAI-PMH
  • OAI-PMH DublinCore
Other Formats
  • JSON

Confirm


Back to MERAL


Back to MERAL