{"_buckets": {"deposit": "2037828f-b089-4fce-82d5-23a663fd9186"}, "_deposit": {"id": "2569", "owners": [], "pid": {"revision_id": 0, "type": "recid", "value": "2569"}, "status": "published"}, "_oai": {"id": "oai:meral.edu.mm:recid/2569", "sets": ["user-uy"]}, "communities": ["ccm", "ccp", "kyauksetu", "ltc", "maas", "miit", "mlmu", "mmu", "mtlu", "mtu", "mub", "mude", "mufl", "pathein", "scu", "suoe", "tcu", "tgu", "tuh", "tum", "ucsm", "ucsmtla", "ucsmub", "ucspathein", "ucstaungoo", "ucsy", "udmm", "udmy", "uit", "um", "um1", "um2", "umkn", "umm", "uphy", "urj", "uvs", "uy", "yau", "ydbu", "ytu", "yude", "yueco", "yufl", "yuoe"], "control_number": "2569", "item_1583103067471": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum", "subitem_1551255648112": "en"}]}, "item_1583103085720": {"attribute_name": "Description", "attribute_value_mlt": [{"interim": "Aim of the study: For identification of the active constituents we investigated the anticancer activity of\r cardenolides from Streptocaulon tomentosum Wight \u0026 Arn. (Asclepiadaceae) and from Nerium oleander L.\r (Apocynaceae) which are both used against cancer in the traditional medicine in their region of origin.\r Material, methods and results: The antiproliferative activity of cardenolides isolated from roots of Streptocaulon\r tomentosum (IC50 \u003c 1–15.3 M after 2 days in MCF7) and of cardenolide containing fractions from\r the cold aqueous extract of Nerium oleander leaves (“Breastin”, mean IC50 0.85 g/ml in a panel of 36\r human tumor cell lines), their influence on the cellular viability and on the cell cycle (block at the G2/Mphase\r or at the S-phase in tumor cells, respectively) were determined using different cell lines. The murine\r cell line L929 and normal non-tumor cells were not affected. Bioactivity guided fractionation of Breastin\r resulted in the isolation of the monoglycosidic cardenolides oleandrine, oleandrigeninsarmentoside,\r neritaloside, odoroside H, and odoroside A (IC50-values between 0.010 and 0.071 g/ml).\r Conclusions: The observed anticancer activities of extracts and isolated cardenolides are in agreement with\r the ethnomedicinal use of Streptocaulon tomentosum and Nerium oleander. The most active anticancer\r compounds from both species are monoglycosidic cardenolides possessing the 3ˇ,14ˇ-dihydroxy-5ˇ-\r card-20(22)-enolide structure with or without an acetoxy group at C-16. The results indicate that the\r cytotoxic effects are induced by the inhibition of the plasma membrane bound Na+/K+-ATPase."}]}, "item_1583103108160": {"attribute_name": "Keywords", "attribute_value_mlt": [{"interim": "Cardenolides"}]}, "item_1583103131163": {"attribute_name": "Journal articles", "attribute_value_mlt": [{"subitem_journal_title": "Journal of Ethnopharmacology"}]}, "item_1583103147082": {"attribute_name": "Conference papaers", "attribute_value_mlt": [{}]}, "item_1583103211336": {"attribute_name": "Books/reports/chapters", "attribute_value_mlt": [{}]}, "item_1583103233624": {"attribute_name": "Thesis/dissertations", "attribute_value_mlt": [{"subitem_supervisor(s)": []}]}, "item_1583105942107": {"attribute_name": "Authors", "attribute_value_mlt": [{"subitem_authors": [{"subitem_authors_fullname": "Rashan, Luay J."}, {"subitem_authors_fullname": "Franke, Katrin"}, {"subitem_authors_fullname": "Myint Myint Khine"}, {"subitem_authors_fullname": "Kelter, Gerhard"}, {"subitem_authors_fullname": "Fiebig, Heinz H."}, {"subitem_authors_fullname": "Neumann, Joachim"}, {"subitem_authors_fullname": "Wessjohann, Ludger A."}]}]}, "item_1583108359239": {"attribute_name": "Upload type", "attribute_value_mlt": [{"interim": "Publication"}]}, "item_1583108428133": {"attribute_name": "Publication type", "attribute_value_mlt": [{"interim": "Journal article"}]}, "item_1583159729339": {"attribute_name": "Publication date", "attribute_value": "2011"}, "item_1583159847033": {"attribute_name": "Identifier", "attribute_value": "http://uyr.uy.edu.mm/handle/123456789/134"}, "item_title": "Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum", "item_type_id": "21", "owner": "1", "path": ["1582967633684"], "permalink_uri": "http://hdl.handle.net/20.500.12678/0000002569", "pubdate": {"attribute_name": "Deposited date", "attribute_value": "2020-03-05"}, "publish_date": "2020-03-05", "publish_status": "0", "recid": "2569", "relation": {}, "relation_version_is_last": true, "title": ["Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum"], "weko_shared_id": -1}