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AN EFFICIENT EXACT SOLUTION TO THE (L, D)-PLANTED MOTIF PROBLEM

http://hdl.handle.net/20.500.12678/0000002349
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1d61c63d-4416-4719-a6e1-41b17fca83be
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An An Efficient exact solution to the (L, D)- planted MOTIF problem.pdf (810 Kb)
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Title
Title AN EFFICIENT EXACT SOLUTION TO THE (L, D)-PLANTED MOTIF PROBLEM
Language en
Publication date 2015
Authors
Sia, Maria Clara Isabel D.
Nabos, Julieta Q.
Fernandez, Proceso L.
Description
DNA motif finding is widely recognized as a difficult problem in computational biology and computer science. Because of the usual large search space involved, exact solutions typically require a significant amount of execution time before discovering a motif of length d that occurs in each sequence Si from an input set {Sl, ...,Sf} of sequences, allowing for at most d substitutions.
In this paper, we propose a novel algorithm that operates on a compact bit-based representation of the search space and takes advantage of distance-related patterns in this representation in order to compute the exact solution for any arbitrary problem instance up to l, d =6.
A Java implementation-run on synthetic datasets for various challenge instances of the (l, d) motif finding problem-shows the proposed algorithm to be highly competitive against PMS8 and qPMS9, two current state-of the- art exact motif search algorithms. The proposed algorithm works extremely well for problems involving short motifs, outperforming the current best algorithm for the challenge problem instances (13,4) and (IS,S) with a runtime reduction of at least 50% and 20% respectively for these instances, while ranking second to qPMS9 for test instances involving l =16 and l =17.
Keywords
DNA motif finding
Identifier https://uyr.uy.edu.mm/handle/123456789/368
Journal articles
8th AUN/SEED-Net Regional Conference on Electrical and Electronics Engineering
Conference papaers
Books/reports/chapters
Thesis/dissertations
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