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Production of Antibacterial Metabolite by Lecancillium waksmanii MKN-09
http://hdl.handle.net/20.500.12678/0000002279
http://hdl.handle.net/20.500.12678/00000022794b3628bc-7de5-4784-9825-8227e2bc0b9d
84f24d35-9621-4140-837a-c82d33cc097f
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Production of Antibacterial Metabolite by Lecanicillium waksmanii MKN-09.pdf (7635 Kb)
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Journal article | ||||||
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Publication | ||||||
Title | ||||||
Title | Production of Antibacterial Metabolite by Lecancillium waksmanii MKN-09 | |||||
Language | en | |||||
Publication date | 2008 | |||||
Authors | ||||||
Khine Swe Nyunt | ||||||
Moe Moe Aye | ||||||
Nyunt Phay | ||||||
Description | ||||||
In the screening program of antimicrobial metabolite, 54 fungi isolated from the soil collected at Chin State and Mandalay Division. In this study, 24 test organisms were utilized for antimicrobial activities. Among these fungi, one fungus showed selective highly antibacterial activity against Methicillin-Resistant Staphylococcus aureus (MRSA). Therefore, this fungus was selected for further investigations such as fermentation, purification and biological properties. Fungus MKN-09 was isolated from the soil collected at Hpa-Lam area, Chin State. MKN-09 was identified as lecanicllium waksmanii. In fermentation studies, metabolite production reached at 6 days fermentation with 200/0 sizes and 66 hrs ages of cultures. Antibacterial metabolite was purified by various chromatographies. It was observed that MIC of this metabolite is 0.3125 µg/ml on MRSA. This metabolite (MKN-Q9) affects on the growth of S. aureus at a concentration of 0.3125 µg/ml; any further increase in its concentration above 0.3125 µg/ml resulted in a more suppressive effect on growth. At a concentration of 1.25 µg/ml, cell lysis was observed that indicating that MKN-Q9 metabolite acts as a bacteriocidal compound. | ||||||
Identifier | https://uyr.uy.edu.mm/handle/123456789/497 | |||||
Journal articles | ||||||
1 | ||||||
Universities Research Journal (URJ) | ||||||
1 | ||||||
Conference papaers | ||||||
Books/reports/chapters | ||||||
Thesis/dissertations |