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  1. University of Yangon
  2. Department of Botany

Production of Antibacterial Metabolite by Lecancillium waksmanii MKN-09

http://hdl.handle.net/20.500.12678/0000002279
http://hdl.handle.net/20.500.12678/0000002279
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84f24d35-9621-4140-837a-c82d33cc097f
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Production Production of Antibacterial Metabolite by Lecanicillium waksmanii MKN-09.pdf (7635 Kb)
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Journal article
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Publication
Title
Title Production of Antibacterial Metabolite by Lecancillium waksmanii MKN-09
Language en
Publication date 2008
Authors
Khine Swe Nyunt
Moe Moe Aye
Nyunt Phay
Description
In the screening program of antimicrobial metabolite, 54 fungi isolated from the soil collected at Chin State and Mandalay Division. In this study, 24 test organisms were utilized for antimicrobial activities. Among these fungi, one fungus showed selective highly antibacterial activity against Methicillin-Resistant Staphylococcus aureus (MRSA). Therefore, this fungus was selected for further investigations such as fermentation, purification and biological properties. Fungus MKN-09 was isolated from the soil collected at Hpa-Lam area, Chin State. MKN-09 was identified as lecanicllium waksmanii. In fermentation studies, metabolite production reached at 6 days fermentation with 200/0 sizes and 66 hrs ages of cultures. Antibacterial metabolite was purified by various chromatographies. It was observed that MIC of this metabolite is 0.3125 µg/ml on MRSA. This metabolite (MKN-Q9) affects on the growth of S. aureus at a concentration of 0.3125 µg/ml; any further increase in its concentration above 0.3125 µg/ml resulted in a more suppressive effect on growth. At a concentration of 1.25 µg/ml, cell lysis was observed that indicating that MKN-Q9 metabolite acts as a bacteriocidal compound.
Identifier https://uyr.uy.edu.mm/handle/123456789/497
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Universities Research Journal (URJ)
1
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