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(Guttiferae), have been in use in Myanmar folk medicine for the treatment of skin infections, wounds, diarrhea and dysentery. The main aim of this work was the use of mangosteen in traditional medicine to get scientific scrutiny. Phytochemical investigations on mangosteen fruit hulls indicated the presence of carbohydrates, glycosides, organic acids, phenolic compounds, reducing sugars, flavonoids and tannins in it. Four xanthones, namely, gartanin (1) (m.p 146-152°C; yield 0.48%), and compound mangostin (2) (m.p 179-181°C, 0.97% yield), p-mangostin (3) (m.p 175°C, 0.063% yield) and nor-mangostin (4) (m.p 196-198°C, 0.91% yield) were isolated and spectroscopically identified from the fruit hulls of mangosteen collected from Kyeik-kaw township of Mon State in June, 2003. Antibacterial activities of crude extracts (petroleum ether and etl.anol extract) by agar disc diffusion method against 33 bacteria strains including Escherichia coli, Shigella spp., Salmonella spp., Staphylococcus aureus, Bacillus substilis, Klaebsiella aerginosa, Proteus morganii, Plesiomonas shigelloides, Pseudomonas PYOCYanea and Vibrio spp. were evaluated. Ethanol extract inhibited the growth of B. substilis and S. aureus as evidenced by zone inhibition diameter measurements (d=14mm for both strains) when compared to standard antibiotic. In addition, 1 and 2 exhibited inhibitory effect against resistant strains of Staphylococcus aureus with the minimum inhibitory concentration (MIC) value of \u003e0.1 mg/ml and 0.05 mg/ml, respectively, showing the superiority of 2 over I. No inhibitory effect was observed against remaining strains indicating narrow antibacterial spectrum of mangosteen crude extract and its constituents. S. aureus and its pathogenic capacity were mentioned that the effect of food poisoning, boils, abscesses and wound sepsis. This study proved mangosteen fruit hulls which are widely used in remedies of traditional medicine are of valuable antibacterial agents especially for S. aureus infection. 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  1. University of Yangon
  2. Department of Chemistry

Isolation, Identification and Antibacterial Activity of Some Xanthones Present In Fruit Hulls of Garcinia Mangostana Linn.

http://hdl.handle.net/20.500.12678/0000002183
http://hdl.handle.net/20.500.12678/0000002183
ea13330e-9d1b-4443-90c6-9f88c27228d5
76eba534-1242-4b48-b8ce-b6450f1585b3
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Isolation, Isolation, Identification and Antibacterial activity of some Xanthones present in fruit Hulls of Garcinia Mangostana Linn..pdf (11332 Kb)
Publication type
Journal article
Upload type
Publication
Title
Title Isolation, Identification and Antibacterial Activity of Some Xanthones Present In Fruit Hulls of Garcinia Mangostana Linn.
Language en
Publication date 2008
Authors
Sandar Aung
Aye Aye Tun
San San Aye
Maung Maung Htay
Description
The fruit hulls of mangosteen, Garcinia mangostana Linn. (Guttiferae), have been in use in Myanmar folk medicine for the treatment of skin infections, wounds, diarrhea and dysentery. The main aim of this work was the use of mangosteen in traditional medicine to get scientific scrutiny. Phytochemical investigations on mangosteen fruit hulls indicated the presence of carbohydrates, glycosides, organic acids, phenolic compounds, reducing sugars, flavonoids and tannins in it. Four xanthones, namely, gartanin (1) (m.p 146-152°C; yield 0.48%), and compound mangostin (2) (m.p 179-181°C, 0.97% yield), p-mangostin (3) (m.p 175°C, 0.063% yield) and nor-mangostin (4) (m.p 196-198°C, 0.91% yield) were isolated and spectroscopically identified from the fruit hulls of mangosteen collected from Kyeik-kaw township of Mon State in June, 2003. Antibacterial activities of crude extracts (petroleum ether and etl.anol extract) by agar disc diffusion method against 33 bacteria strains including Escherichia coli, Shigella spp., Salmonella spp., Staphylococcus aureus, Bacillus substilis, Klaebsiella aerginosa, Proteus morganii, Plesiomonas shigelloides, Pseudomonas PYOCYanea and Vibrio spp. were evaluated. Ethanol extract inhibited the growth of B. substilis and S. aureus as evidenced by zone inhibition diameter measurements (d=14mm for both strains) when compared to standard antibiotic. In addition, 1 and 2 exhibited inhibitory effect against resistant strains of Staphylococcus aureus with the minimum inhibitory concentration (MIC) value of >0.1 mg/ml and 0.05 mg/ml, respectively, showing the superiority of 2 over I. No inhibitory effect was observed against remaining strains indicating narrow antibacterial spectrum of mangosteen crude extract and its constituents. S. aureus and its pathogenic capacity were mentioned that the effect of food poisoning, boils, abscesses and wound sepsis. This study proved mangosteen fruit hulls which are widely used in remedies of traditional medicine are of valuable antibacterial agents especially for S. aureus infection. It may be used in the treatment of amoebic dysentery; however, it should not be used for bacillary dysentery which is caused by members of the genus Shigella.
Keywords
mangosteen
Identifier https://uyr.uy.edu.mm/handle/123456789/514
Journal articles
3
Universities Research Journal (URJ)
1
Conference papaers
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