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Item

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Kaempulchraols IeO: new isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their antiproliferative activity

http://hdl.handle.net/20.500.12678/0000001999
b3b8540a-df76-4f33-9caf-1e81ff415ffa
7bb5c6a1-b2cb-4b5c-8208-bf9e445bc83b
Publication type
Journal article
Upload type
Publication
Title
Title Kaempulchraols IeO: new isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their antiproliferative activity
Language en
Publication date 2015
Authors
Nwet Nwet Win
Ito, Takuya
Aimaiti, Simayijiang
Kodama, Takeshi
Imagawa, Hiroshi
Hla Ngwe
Asakawa, Yoshinori
Abe, Ikuro
Morita, Hiroyuki
Description
The isolation of the CHCl3 soluble extract of Kaempferia pulchra rhizomes afforded seven new isopimarane
diterpenoids, kaempulchraols IeO, together with one known analog. The structures of these
compounds were elucidated using 1D and 2D NMR and X-ray diffraction analyses. The antiproliferative
activity of the isolated compounds was evaluated against a panel of five human cancer cell lines.
Kaempulchraol L exhibited weak antiproliferative activity against PANC-1 and PSN-1 cells with IC50
values of 39.9 and 22.6 mM, respectively.
Keywords
Kaempferia pulchra
Identifier http://uyr.uy.edu.mm/handle/123456789/119
Journal articles
Conference papaers
Books/reports/chapters
Thesis/dissertations
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