MERAL Myanmar Education Research and Learning Portal
Item
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Kaempulchraols IeO: new isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their antiproliferative activity
http://hdl.handle.net/20.500.12678/0000001999
http://hdl.handle.net/20.500.12678/0000001999b3b8540a-df76-4f33-9caf-1e81ff415ffa
7bb5c6a1-b2cb-4b5c-8208-bf9e445bc83b
Publication type | ||||||
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Journal article | ||||||
Upload type | ||||||
Publication | ||||||
Title | ||||||
Title | Kaempulchraols IeO: new isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their antiproliferative activity | |||||
Language | en | |||||
Publication date | 2015 | |||||
Authors | ||||||
Nwet Nwet Win | ||||||
Ito, Takuya | ||||||
Aimaiti, Simayijiang | ||||||
Kodama, Takeshi | ||||||
Imagawa, Hiroshi | ||||||
Hla Ngwe | ||||||
Asakawa, Yoshinori | ||||||
Abe, Ikuro | ||||||
Morita, Hiroyuki | ||||||
Description | ||||||
The isolation of the CHCl3 soluble extract of Kaempferia pulchra rhizomes afforded seven new isopimarane diterpenoids, kaempulchraols IeO, together with one known analog. The structures of these compounds were elucidated using 1D and 2D NMR and X-ray diffraction analyses. The antiproliferative activity of the isolated compounds was evaluated against a panel of five human cancer cell lines. Kaempulchraol L exhibited weak antiproliferative activity against PANC-1 and PSN-1 cells with IC50 values of 39.9 and 22.6 mM, respectively. |
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Keywords | ||||||
Kaempferia pulchra | ||||||
Identifier | http://uyr.uy.edu.mm/handle/123456789/119 | |||||
Journal articles | ||||||
Conference papaers | ||||||
Books/reports/chapters | ||||||
Thesis/dissertations |