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Item

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  1. University of Yangon
  2. Department of Chemistry

Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar

http://hdl.handle.net/20.500.12678/0000001921
http://hdl.handle.net/20.500.12678/0000001921
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6ad9284e-c5cc-4ca7-86ab-3b361ef2c732
Publication type
Journal article
Upload type
Publication
Title
Title Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar
Language en
Publication date 2008
Authors
Nwet Nwet Win
Awale, Suresh
Esumi, Hiroyasu
Tezuka, Yasuhiro
Kadota, Shigetoshi
Description
The CHCl3-soluble fraction of 70% EtOH extract of the flower of Kayea assamica completely killed human
pancreatic PANC-1 cancer cells preferentially under nutrient-deprived conditions at 1 lg/mL. Bioassayguided
fractionation and isolation afforded two novel compounds, kayeassamins A (1) and B (2). Their
structures were elucidated using extensive spectroscopic methods and the modified Mosher method.
Each compound showed 100% preferential cytotoxicity (PC100) against PANC-1 cells under nutrientdeprived
conditions at 1 lM. Furthermore, both compounds inhibited the migration of PANC-1 cells in
the wound closure assay.
Keywords
Anti-austerity strategy
Identifier http://uyr.uy.edu.mm/handle/123456789/117
Journal articles
Conference papaers
Books/reports/chapters
Thesis/dissertations
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