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New Index
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Item
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Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar
http://hdl.handle.net/20.500.12678/0000001921
http://hdl.handle.net/20.500.12678/0000001921c948d2c0-6755-42a5-a187-575ead3282b8
6ad9284e-c5cc-4ca7-86ab-3b361ef2c732
Publication type | ||||||
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Journal article | ||||||
Upload type | ||||||
Publication | ||||||
Title | ||||||
Title | Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar | |||||
Language | en | |||||
Publication date | 2008 | |||||
Authors | ||||||
Nwet Nwet Win | ||||||
Awale, Suresh | ||||||
Esumi, Hiroyasu | ||||||
Tezuka, Yasuhiro | ||||||
Kadota, Shigetoshi | ||||||
Description | ||||||
The CHCl3-soluble fraction of 70% EtOH extract of the flower of Kayea assamica completely killed human pancreatic PANC-1 cancer cells preferentially under nutrient-deprived conditions at 1 lg/mL. Bioassayguided fractionation and isolation afforded two novel compounds, kayeassamins A (1) and B (2). Their structures were elucidated using extensive spectroscopic methods and the modified Mosher method. Each compound showed 100% preferential cytotoxicity (PC100) against PANC-1 cells under nutrientdeprived conditions at 1 lM. Furthermore, both compounds inhibited the migration of PANC-1 cells in the wound closure assay. |
||||||
Keywords | ||||||
Anti-austerity strategy | ||||||
Identifier | http://uyr.uy.edu.mm/handle/123456789/117 | |||||
Journal articles | ||||||
Conference papaers | ||||||
Books/reports/chapters | ||||||
Thesis/dissertations |