MERAL Myanmar Education Research and Learning Portal
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Kaempulchraols A−H, Diterpenoids from the Rhizomes of Kaempferia pulchra Collected in Myanmar
http://hdl.handle.net/20.500.12678/0000001862
http://hdl.handle.net/20.500.12678/00000018628924c660-bc35-4534-aaf1-551ea6137fa4
15e7b87d-8d1d-4d7a-aba4-4e6dbd5c561f
Publication type | ||||||
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Journal article | ||||||
Upload type | ||||||
Publication | ||||||
Title | ||||||
Title | Kaempulchraols A−H, Diterpenoids from the Rhizomes of Kaempferia pulchra Collected in Myanmar | |||||
Language | en | |||||
Publication date | 2015 | |||||
Authors | ||||||
Nwet Nwet Win | ||||||
Ito, Takuya | ||||||
Aimaiti, Simayijiang | ||||||
Imagawa, Hiroshi | ||||||
Hla Ngwe | ||||||
Abe, Ikuro | ||||||
Morita, Hiroyuki | ||||||
Description | ||||||
Eight new diterpenoids, kaempulchraols A–H (1–8), along with five known analogues were isolated from the CHCl3-soluble extract of rhizomes of Kaempferia pulchra of Myanmar. The structures of these compounds were elucidated using extensive spectroscopic techniques including X-ray diffraction analysis. All the isolates were tested for their antiproliferative activity against a panel of five human cancer cell lines (A549, human lung cancer; HeLa, human cervix cancer; PANC-1 and PSN-1, human pancreatic cancer; MDA-MB-231, human breast cancer) and TIG-3, normal human primary fibroblast cells. Kaempulchraol F (6) exhibited weak activity against the human pancreatic PSN-1 cell line with an IC50 value of 12.3 μM. | ||||||
Identifier | http://uyr.uy.edu.mm/handle/123456789/121 | |||||
Journal articles | ||||||
Conference papaers | ||||||
Books/reports/chapters | ||||||
Thesis/dissertations |