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Kaempulchraols A−H, Diterpenoids from the Rhizomes of Kaempferia pulchra Collected in Myanmar

http://hdl.handle.net/20.500.12678/0000001862
8924c660-bc35-4534-aaf1-551ea6137fa4
15e7b87d-8d1d-4d7a-aba4-4e6dbd5c561f
Publication type
Journal article
Upload type
Publication
Title
Title Kaempulchraols A−H, Diterpenoids from the Rhizomes of Kaempferia pulchra Collected in Myanmar
Language en
Publication date 2015
Authors
Nwet Nwet Win
Ito, Takuya
Aimaiti, Simayijiang
Imagawa, Hiroshi
Hla Ngwe
Abe, Ikuro
Morita, Hiroyuki
Description
Eight new diterpenoids, kaempulchraols A–H (1–8), along with five known analogues were isolated from the CHCl3-soluble extract of rhizomes of Kaempferia pulchra of Myanmar. The structures of these compounds were elucidated using extensive spectroscopic techniques including X-ray diffraction analysis. All the isolates were tested for their antiproliferative activity against a panel of five human cancer cell lines (A549, human lung cancer; HeLa, human cervix cancer; PANC-1 and PSN-1, human pancreatic cancer; MDA-MB-231, human breast cancer) and TIG-3, normal human primary fibroblast cells. Kaempulchraol F (6) exhibited weak activity against the human pancreatic PSN-1 cell line with an IC50 value of 12.3 μM.
Identifier http://uyr.uy.edu.mm/handle/123456789/121
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