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  1. University of Yangon
  2. Department of Chemistry

Bioactive Secondary Metabolites from Boesenbergia pandurata of Myanmar and Their Preferential Cytotoxicity against Human Pancreatic Cancer PANC-1 Cell Line in Nutrient-Deprived Medium

http://hdl.handle.net/20.500.12678/0000001805
http://hdl.handle.net/20.500.12678/0000001805
ee603e4e-734c-44ec-a619-557c9473e970
0db54c0e-6535-4543-8a9e-ef9877de46a7
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Bioactive Bioactive Secondary Metabolites.pdf (136 Kb)
Publication type
Journal article
Upload type
Publication
Title
Title Bioactive Secondary Metabolites from Boesenbergia pandurata of Myanmar and Their Preferential Cytotoxicity against Human Pancreatic Cancer PANC-1 Cell Line in Nutrient-Deprived Medium
Language en
Publication date 2007
Authors
Nwet Nwet Win
Awale, Suresh
Esumi, Hiroyasu
Tezuka, Yasuhiro
Kadota, Shigetoshi
Description
The chloroform extract of rhizomes of Boesenbergia pandurata demonstrated marked preferential cytotoxicity against
human pancreatic PANC-1 cancer cells in nutrient-deprived medium. Bioactivity-directed investigation of this extract
yielded four new secondary metabolites, geranyl-2,4-dihydroxy-6-phenethylbenzoate (1), 2′,4′-dihydroxy-3′-(1′′-geranyl)-
6′-methoxychalcone (2), (1′R,2′S,6′R)-2-hydroxyisopanduratin A (3), and (2R)-8-geranylpinostrobin (4), and twenty
known compounds (5–24). Among the known compounds, (2S)-6-geranylpinostrobin (5), (()-6-methoxypanduratin A
(6), and (2S)-7,8-dihydro-5-hydroxy-2-methyl-2-(4′′-methyl-3′′-pentenyl)-8-phenyl-2H,6H-benzo[1,2-b:5,4-b′]dipyran-6-one
(7) were isolated for the first time from a natural source. The structures of these compounds were elucidated using
extensive spectroscopic techniques including CD measurements. All the isolated compounds showed varying degrees
of in Vitro preferential cytotoxicity against PANC-1 cells. Nicolaioidesin B (11) and panduratin A (17) were most
potent, each showing a PC100 at 2.5 µM.
Identifier http://uyr.uy.edu.mm/handle/123456789/125
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