{"created":"2024-03-15T14:59:06.037787+00:00","id":9368,"links":{},"metadata":{"_buckets":{"deposit":"a2488104-e57d-4335-a323-d1405c03deca"},"_deposit":{"created_by":12,"id":"9368","owner":"12","owners":[12],"owners_ext":{"displayname":"","email":"hlaingyu2010@gmail.com","username":""},"pid":{"revision_id":0,"type":"depid","value":"9368"},"status":"published"},"_oai":{"id":"oai:meral.edu.mm:recid/00009368","sets":["1582963390870:1582967633684"]},"author_link":[],"item_1583103067471":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"ISOLATION OF BIOLOGICALLY ACTIVE COMPOUNDS FROM BARK OF HOLOPTELEA INTEGRIFOLIA R. (PHYAUK-SEIK)","subitem_1551255648112":"en"}]},"item_1583103085720":{"attribute_name":"Description","attribute_value_mlt":[{"interim":"One of the sources of bioactive compounds and a potential source of new therapeutic medicines are medicinal plants. Due to its traditional therapeutic benefits for the treatment and prevention of numerous ailments, Holoptelea integrifolia Roxb. (Ulmaceae) is a well-known medicinal plant in Myanmar. The purpose of this study is to separate various organic components from the bark of H. integrifolia (Phyauk-seik) and assess the principal isolated compound's in vitro anti-arthritic and anti-diabetic effects. Three chemicals, including TZNO-I, TZNO-II, and TZNO-III, were extracted from the plant's bark. An advanced spectroscopic method like Fourier Transform Infrared Spectroscopy (FT IR) was used to determine the structures of the isolated chemicals because these structures were also compared to authentic structures. According to the findings of the protein denaturation method used to assess anti-arthritic activity, TZNO-III exhibited considerable activity against both egg albumin and bovine serum albumin that was concentration-dependent and increased in percentage protection at 1600 g/mL. Comparing TZNO-III to the two common medications metformin and acarbose revealed that it likewise has mild anti-diabetic activity on the -amylase and -glucosidase enzymes with IC50 values of 56.72 g/mL and 40.63 g/mL."}]},"item_1583103108160":{"attribute_name":"Keywords","attribute_value_mlt":[{"interim":"Holoptelea integrifolia"},{"interim":"anti-arthritic"},{"interim":"anti-diabetic"},{"interim":"protein denaturation method"}]},"item_1583103120197":{"attribute_name":"Files","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-15"}],"displaytype":"preview","filename":"Thazin Nwe Oo (375 to 386 ).pdf","filesize":[{"value":"632 KB"}],"format":"application/pdf","licensetype":"license_3","url":{"url":"https://meral.edu.mm/record/9368/files/Thazin Nwe Oo (375 to 386 ).pdf"},"version_id":"e7579ca5-1380-42fc-a493-01ffec474c0b"}]},"item_1583103131163":{"attribute_name":"Journal articles","attribute_value_mlt":[{"subitem_issue":"2022","subitem_journal_title":"University of Yangon Research Journal","subitem_pages":"375-386","subitem_volume":"11, No. 1"}]},"item_1583105942107":{"attribute_name":"Authors","attribute_value_mlt":[{"subitem_authors":[{"subitem_authors_fullname":"Tha Zin Nwe Oo1"},{"subitem_authors_fullname":"Mya Thandar Aung2"},{"subitem_authors_fullname":"Saw Hla Myint3"}]}]},"item_1583108359239":{"attribute_name":"Upload type","attribute_value_mlt":[{"interim":"Publication"}]},"item_1583108428133":{"attribute_name":"Publication type","attribute_value_mlt":[{"interim":"Journal article"}]},"item_1583159729339":{"attribute_name":"Publication date","attribute_value":"2022-12-31"},"item_title":"ISOLATION OF BIOLOGICALLY ACTIVE COMPOUNDS FROM BARK OF HOLOPTELEA INTEGRIFOLIA R. (PHYAUK-SEIK)","item_type_id":"21","owner":"12","path":["1582967633684"],"publish_date":"2024-03-15","publish_status":"0","recid":"9368","relation_version_is_last":true,"title":["ISOLATION OF BIOLOGICALLY ACTIVE COMPOUNDS FROM BARK OF HOLOPTELEA INTEGRIFOLIA R. (PHYAUK-SEIK)"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-03-15T15:04:30.198422+00:00"}