{"created":"2020-08-30T20:03:07.211939+00:00","id":3155,"links":{},"metadata":{"_buckets":{"deposit":"61514b2a-18bb-4fd5-9186-58a5f0b642c1"},"_deposit":{"id":"3155","owners":[],"pid":{"revision_id":0,"type":"recid","value":"3155"},"status":"published"},"_oai":{"id":"oai:meral.edu.mm:recid/3155","sets":["1582963366982:1596631759527"]},"communities":["um1"],"item_1583103067471":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Effects of Diclofenac and Ibuprofen on Pharmacokinetics of Ciprofloxacin in Myanmar Healthy Volunteers","subitem_1551255648112":""}]},"item_1583103085720":{"attribute_name":"Description","attribute_value_mlt":[{"interim":"
The present study was done to explore the pharmacokinetics of ciprofloxacinthat was altered by co-administration of either diclofenac or ibuprofen. The study was conducted on twelve Myanmar healthy volunteers and divided into three phases with a wash out period of one week in between phases. In phase, ciprofloxacin 500 mg was given to all volunteers, ciprofloxacin 500 mg with diclofenac 50 mg was given to same volunteers in phase 2 and ciprofloxacin 500 mg with ibuprofen 400 mg was given in phase 3. Blood samples were collected at 0, 0.5, 1, 2, 3, 4, 6 and 8 hours\\ after drugs administration and ciprofloxacin concentrations in plasma samples were analyzed by HPLC with UV detection. It was found that mean clearance was reduced from 0.38±0.11 Lhr-1kg-1 in ciprofloxacin alone to 0.30±0.07 Lhr-1kg-1 and 0.28±0.09 Lhr-1kg-1 in ciprofloxacin with diclofenac and ciprofloxacin with ibuprofen (p=0.019). Similarly, the mean elimination rate constants (Kel) was significantly reduced from 0.24±0.03 hr-1 in ciprofloxacin alone to 0.18±0.024 hr-1 in ciprofloxacin with diclofenac and 0.12±0.03 hr-1 in ciprofloxacin with ibuprofen co-administration (p=0.000). Increase in AUC of ciprofloxacin was founded that AUC of ciprofloxacin alone was 13.51±1.91 μgml-1.hr, ciprofloxacin with diclofenac was 17.36±2.67 μgml-1.hr and with ibuprofen was 18.43±4.08 μgml-1.hr, respectively (p=0.001).
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