{"created":"2020-08-30T20:01:31.484995+00:00","id":3138,"links":{},"metadata":{"_buckets":{"deposit":"e833bcdb-fe62-492c-aec9-80b4e9a1157f"},"_deposit":{"id":"3138","owners":[],"pid":{"revision_id":0,"type":"recid","value":"3138"},"status":"published"},"_oai":{"id":"oai:meral.edu.mm:recid/3138","sets":["1582963366982:1596631591423"]},"communities":["um1"],"item_1583103067471":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Induction of matrix metalloproteinase'1 in in vitro experimental wound model using a novel three-dimensional culture system","subitem_1551255648112":""}]},"item_1583103085720":{"attribute_name":"Description","attribute_value_mlt":[{"interim":"
The aim of this study was to determine whether experimentally punched wounds may influence the connective tissue metabolism of human fibroblast in a three dimensional culture supplemented with L-ascorbic acid. This culture was designed for human dermal
\nfibroblasts to organize a three-dimensional dermis-like structure by accumulating self-produced extracellular matrixes. In order to examine the effects of the wound, mRNA expression and production of type I collagen, matrix metalloproteinase-1 (MMP-1) and
\ntissue inhibitors of metalloproteinase-1 (TIMP-1) were sequentially examined up to 72 hrs after the wound was created.