{"created":"2020-08-30T20:01:27.698975+00:00","id":3137,"links":{},"metadata":{"_buckets":{"deposit":"b0d96da3-c5fd-4804-9cad-b6f042e855cb"},"_deposit":{"id":"3137","owners":[],"pid":{"revision_id":0,"type":"recid","value":"3137"},"status":"published"},"_oai":{"id":"oai:meral.edu.mm:recid/3137","sets":["1582963366982:1596631591423"]},"communities":["um1"],"item_1583103067471":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Catalase restores the altered mRNA expression of collagen and matrix metalloproteinases by dermal fibroblasts exposed to reactive oxygen species","subitem_1551255648112":""}]},"item_1583103085720":{"attribute_name":"Description","attribute_value_mlt":[{"interim":"
We investigated the effects of reactive oxygen species (ROS) on mRNA expression of proalphal (l) collagen, proalphal (lll) collagen, matrix metalloproteinases-1 (MMP-1), 72 kDa type lV collagenase (MMP-2), and tissue inhibitor of metalloproteinase (TIMP-1) by normal human dermal fibroblasts in a novel three-dimensional culture. Fibroblasts exposed to ROS generated by the hypoxanthine-xanthine oxidase system revealed an increased mRNAexpression of MMP-1 and MMP-2 with a maximum at48 h and 72h after
\nexposure. A slight increase in the mRNA level of tissue inhibitor of metalloproteinase (TIMP-1) was observed.