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  1. University of Yangon
  2. Department of Chemistry

An-Antioxidant Organie Compound Isolated from the Stem of Hypericum calycinum L. (Pyin-nyar-lin-kar)

http://hdl.handle.net/20.500.12678/0000002488
http://hdl.handle.net/20.500.12678/0000002488
5f1d0e29-1a56-4179-9568-684de29b6ff1
406d14f5-4c08-4cf6-819e-1dca1596a161
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An An Antioxidant Organic compound isolated from the stem of Hypericum calycinum L. (Pyin-nyar-lin-kar).pdf (4460 Kb)
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Journal article
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Publication
Title
Title An-Antioxidant Organie Compound Isolated from the Stem of Hypericum calycinum L. (Pyin-nyar-lin-kar)
Language en
Publication date 2008
Authors
Thida Win
Thant Thant Htwe
Heilmann, Joerg
Myint Myint Sein
Description
In the present study, stem of Hypericum calycinum L. (Pyin-nyar-lin-kar in Myanmar), which is mainly used in the treatment of malaria in Myanmar Traditional Medicinal System, was selected for chemical investigation. The preliminary phytochemical screening of the stem of this plant was performed. Moreover, ant bacterial tests of the crude extracts of this plant sample were done by agar well diffusion method in various solvents on six selected organisms. The antioxidant activities of three crude extracts of Hypericum ca/ycinum L. were determined by using 1-1-diphenyl-2-picryl hydrazyl (DPPH) assay. In addition, the pure colourless crystal was isolated from the ethyl acetate extract of the stem of Hypericum calycinum L. by using loin Layer and Column
Chromatographic methods. The phytochemical test of this compound gave positive result for flavonoid group only. The molecular formula of this compound could be assigned as C25H28O6 based upon some advanced spectroscopic methods. The complete structure of this new compound was elucidated on the basis of 10 and 2D-NMR analysis as well as mass spectrometry (EI and HR-MS). The scientific name of this elucidated compound is named as 5-hydroxy-2S-[2, 4, 6-trihydroxy)-3-(2isoprophenyl- 5-methyl-hex-4-enyl) phenyl]-chroman-4 one. In order to know the antioxidant activity of this compound, Oxygen Radical Absorbance Capacity (ORAC) assay was performed. Moreover, cytotoxic activity of this compound was done by Colorimetric MTT (tetrazolium) assay on HeLa human cervix carcinoma cell and Coca-2 human epithelial colorectal adenocarcinoma cell.
Keywords
Hypericum calycinum L.
Identifier https://uyr.uy.edu.mm/handle/123456789/517
Journal articles
3
Universities Research Journal (URJ)
1
Conference papaers
Books/reports/chapters
Thesis/dissertations
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