2024-03-28T23:36:41Z
https://meral.edu.mm/oai
oai:meral.edu.mm:recid/3127
2021-12-13T05:47:44Z
1582963366982:1597649530495
user-um1
Single Nucleotide Polymorphism at +276 G>T of the Adiponectin Gene and Plasma Adiponectin Level in Myanmar Type 2 Diabetic Patients
Khin Thin Yu
Kyu Kyu Maung
Aye Thida
Thein Myint
<p>Abstract<br>
Objective. The aim of the study was to investigate the association between single nucleotide polymorphisms (SNP) at<br>
rs 1501299 (SNP+276 G>T) of the adiponectin gene and plasma adiponectin levels in type 2 diabetes mellitus (T2DM)<br>
patients in Myanmar.<br>
Methodology. One hundred T2DM patients and 104 non-diabetic subjects were included in this cross-sectional analytical<br>
study. Genotype frequencies were determined by polymerase chain reaction - restriction fragment length polymorphism<br>
(PCR-RFLP) method. Plasma adiponectin level was measured by enzyme-linked immunosorbent assay (ELISA).<br>
Result. Genotype frequencies (GG, GT, TT) of SNP+276 in diabetic patients were 39%, 48% and 13%, respectively. The<br>
GT and TT genotypes were more frequent in T2DM patients (OR 1.98, 95% CI, 1.10-3.55; p=0.02 and OR 4.07, 95%<br>
CI, 1.34-12.3; p=0.01), respectively. The T allele of SNP+276 was significantly associated with T2DM (OR 1.96, 95% CI,<br>
1.27-3.01; p=0.002). Mean plasma adiponectin level was significantly lower than in T2DM patients (27.41±16.7 μg/mL)<br>
compared to non-diabetic subjects (37.19±26.77 μg/mL) (p=0.002).<br>
Conclusion. SNP+276 at rs 1501299 of the adiponectin gene was associated with type 2 diabetes and low plasma<br>
adiponectin levels in this Myanmar population.</p>
2018-11-28
http://hdl.handle.net/20.500.12678/0000003127
https://meral.edu.mm/records/3127