2024-03-29T01:02:44Z
https://meral.edu.mm/oai
oai:meral.edu.mm:recid/1890
2021-12-13T03:12:44Z
1582963390870:1582967633684
user-uy
Investigation of the Bioactive Principles and α-Glucosidase Inhibitory Effect of some Myanmar Traditional Medicinal Plants
Hla Ngwe
Khin Chaw Win
May Mon Kyaw
Thaw Thaw Zin
Kyaw Thu
San San Maw
This research is focused on the evaluation of a-glucosidase inhibitors from eight Myanmar
traditional medicinal plants such as Ammomum xanthoides Wall., Commelina communis Linn.,
Crataeva religiosa Forst., Eupatorium odoratum Linn., Gynura procumbens (Lour.) Merr.,
Momordica charantia Linn., Spirulina and Syzygium grande (WI) Walp.. All of these medicinal
plants have been reported to possess the antidiabetic potential. In the present work, watery and
ethanolic extracts, and some isolated compounds such as lupeol, lupeol acetate, friedelin, betulinic
acid, gallic acid, stigmasterol, taraxasterol, B-sitosterol-B-D-glucoside, stearic acid, B-sitosterol,
vitamin C, charatin and A. xanthoides essential oil were used to investigate their inhibitory effect on a-
glucosidase enzyme activity. All of the selected medicinal plant extracts (IC50 = 0.14 ~ 2.07 µg/ml) as
well as the isolated compounds (IC50 = 0.47 ~ 1.91 µg/ml) were found to show the a-glucosidase
inhibitory activity. These values were found to be comparable with Voglibose (IC50 = 0.32 µg/ml),
which was used as a reference in this study. Therefore these plants may be used as sources of natural
a-glucosidase inhibitors in control or management of the postprandial hyperglycemia, Type 2 diabetes.
2012
http://hdl.handle.net/20.500.12678/0000001890
https://meral.edu.mm/records/1890