2026-04-29T23:22:46Z https://meral.edu.mm/oai

oai:meral.edu.mm:recid/3198 2021-12-13T05:39:32Z 1582963366982:1596631786153 user-um1

Impact of heart-specific disruption of the circadian clock on systemic glucose metabolism in mice Tomomi Nakao Akira Kohsaka Tsuyoshi Otsuka Zaw Lin Thein Hue Thi Le Hidefumi Waki Sabine S Gouraud Hayato Ihara Masako Nakanishi Fuyuki Sato Yasuteru Muragaki Masanobu Maeda <p>The daily rhythm of glucose metabolism is governed by the circadian clock, which consists of cellautonomous clock machineries residing in nearly every tissue in the body. Disruption of these clock machineries either environmentally or genetically induces the dysregulation of glucose metabolism. Although the roles of clock machineries in the regulation of glucose metabolism have been uncovered in major metabolic tissues, such as the pancreas, liver, and skeletal muscle, it remains unknown whether clock function in non-major metabolic tissues also affects systemic glucose metabolism. Here, we tested the hypothesis that disruption of the clock machinery in the heart might also affect systemic glucose metabolism, because heart function is known to be associated with glucose tolerance</p> 2017-12-22 http://hdl.handle.net/20.500.12678/0000003198 https://meral.edu.mm/records/3198