2026-06-27T08:59:43Z https://meral.edu.mm/oai

oai:meral.edu.mm:recid/3194 2021-12-13T02:50:33Z 1582963366982:1596631786153 user-um1

Insulin Receptor Substrate-1 Gene (G972R) Polymorphism and Insulin Resistance in Overweight and Obese Type 2 Diabetes Mellitus Patients Thae Nu Htwe Myat Mon Oo Saw Wut Hmon Moh Moh Htun Ohnmar Myint Thein Myat Thandar <p>The insulin receptor substrate-1 gene (IRS-1) gene has been considered a candidate for insulin resistance in type-2 diabetes and coronary artery disease. The most common IRS-1 variant, a glycine to arginine change at codon 972(G972R) is more prevalent among subjects who have features of insulin resistance syndrome associated with type 2 diabetes patients. The aim of the present study was to determine the insulin receptor substrate-1 gene (G972R) polymorphism and insulin resistance in overweight and obese type 2 diabetes mellitus patients. The genomic DNA of the subjects was amplified by polymerase chain reaction (PCR) and digested by restriction fragment length polymorphism (RFLP) with BstN1 used for codon 972.</p> 2015-12-24 http://hdl.handle.net/20.500.12678/0000003194 https://meral.edu.mm/records/3194