2026-08-25T23:02:09Z https://meral.edu.mm/oai

oai:meral.edu.mm:recid/3155 2021-12-13T00:37:38Z 1582963366982:1596631759527 user-um1

Effects of Diclofenac and Ibuprofen on Pharmacokinetics of Ciprofloxacin in Myanmar Healthy Volunteers Aye Pwint Phyu Nang Hla Hla Win Khin Thein Oo Khin Chit Khin Hnin Pwint Thinzar Myo <p>The present study was done to explore the pharmacokinetics of ciprofloxacinthat was altered by co-administration of either diclofenac or&nbsp;ibuprofen. The study was conducted on twelve Myanmar healthy volunteers&nbsp;and divided into three phases with a wash out period of one week in&nbsp;between phases. In phase, ciprofloxacin 500 mg was given to all volunteers,&nbsp;ciprofloxacin 500 mg with diclofenac 50 mg was given to same volunteers&nbsp;in phase 2 and ciprofloxacin 500 mg with ibuprofen 400 mg was given in&nbsp;phase 3. Blood samples were collected at 0, 0.5, 1, 2, 3, 4, 6 and 8 hours\&nbsp;after drugs administration and ciprofloxacin concentrations in plasma&nbsp;samples were analyzed by HPLC with UV detection. It was found that&nbsp;mean clearance was reduced from 0.38&plusmn;0.11 Lhr-1kg-1 in ciprofloxacin&nbsp;alone to 0.30&plusmn;0.07 Lhr-1kg-1 and 0.28&plusmn;0.09 Lhr-1kg-1 in ciprofloxacin with&nbsp;diclofenac and ciprofloxacin with ibuprofen (p=0.019). Similarly, the mean&nbsp;elimination rate constants (Kel) was significantly reduced from 0.24&plusmn;0.03 hr-1&nbsp;in&nbsp;ciprofloxacin alone to 0.18&plusmn;0.024 hr-1 in ciprofloxacin with diclofenac&nbsp;and 0.12&plusmn;0.03 hr-1 in ciprofloxacin with ibuprofen co-administration&nbsp;(p=0.000). Increase in AUC of ciprofloxacin was founded that AUC of&nbsp;ciprofloxacin alone was 13.51&plusmn;1.91 &mu;gml-1.hr, ciprofloxacin with diclofenac&nbsp;was 17.36&plusmn;2.67 &mu;gml-1.hr and with ibuprofen was 18.43&plusmn;4.08 &mu;gml-1.hr,&nbsp;respectively (p=0.001).</p> 2015-10-20 http://hdl.handle.net/20.500.12678/0000003155 https://meral.edu.mm/records/3155