2026-06-27T01:34:37Z https://meral.edu.mm/oai

oai:meral.edu.mm:recid/3142 2022-03-24T23:17:19Z 1582963366982:1596631611229 user-um1

The Prevalence of Helicobacter pylori Virulence Factors in Bhutan, Vietnam, and Myanmar Is Related to Gastric Cancer Incidence Tran Thi Huyen Trang Seiji Shiota Miyuki Matsuda Tran Thanh Binh Rumiko Suzuki Ratha-korn Vilaichone VarochaMahachai Lotay Tshering Ho D. Q. Dung Tomohisa Uchida OsamuMatsunari TheinMyint Vu Van Khien Yoshio Yamaoka Gastric cancer is a significant health problem in Asia. Although the prevalence of Helicobacter pylori infection is similar in Bhutan, Vietnam, andMyanmar, the incidence of gastric cancer is highest in Bhutan, followed by VietnamandMyanmar.We hypothesized that H. pylori virulence factors contribute to the differences. The status of cagA, vacA, jhp0562, and 𝛽-(1,3)galT(jhp0563) was examined in 371 H. pylori-infected patients from Bhutan, Vietnam, and Myanmar. Each virulence factor could not explain the difference of the incidence of gastric cancer.However, the prevalence of quadruple-positive for cagA, vacA s1, vacA m1, and jhp0562- positive/𝛽-(1,3)galT-negative was significantly higher in Bhutan than in Vietnam andMyanmar and correlated with gastric cancer incidence. Moreover, gastritis-staging scores measured by histology of gastric mucosa were significantly higher in quadruplepositive strains.We suggest that the cagA, vacA s1, vacA m1, and jhp0562-positive/𝛽-(1,3)galT-negative genotype may play a role in the development of gastric cancer. 2015-10-11 http://hdl.handle.net/20.500.12678/0000003142 https://meral.edu.mm/records/3142