2026-06-24T23:57:48Z https://meral.edu.mm/oai

oai:meral.edu.mm:recid/3140 2021-12-13T05:47:41Z 1582963366982:1596631591423 user-um1

Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines Gyi Aung Francois Niyonsaba Hiroko Ushio Naoki Kajiwara Hirohisa Saito Shigaku Ikeda Hideoki Ogawa Ko Okumura <p>Catestatin, a neuroendocrine peptide with effects on human autonomic&nbsp;function, has recently been found to be a cutaneous antimicrobial peptide.&nbsp;Human catestatin exhibits three single nucleotide polymorphisms: Gly364-&nbsp;Ser, Pro370Leu and Arg374Gln. Given reports indicating that antimicrobial&nbsp;peptides and neuropeptides induce mast cell activation, we postulated&nbsp;that catestatin might stimulate numerous functions of human mast cells,&nbsp;thereby participating in the regulation of skin inflammatory responses.&nbsp;Catestatin and its naturally occurring variants caused the human mast cell&nbsp;line LAD2 and peripheral blood-derived mast cells to migrate, degranulate&nbsp;and release leukotriene C4 and prostaglandins D2 and E2. Moreover,&nbsp;catestatins increased intracellular Ca2+ mobilization in mast cells, and&nbsp;induced the production of pro-inflammatory cytokines/chemokines such&nbsp;as granulocyte&ndash;macrophage colony-stimulating factor, monocyte chemotactic&nbsp;protein-1/CCL2, macrophage inflammatory protein-1a/CCL3 and<br> macrophage inflammatory protein-1b/CCL4.</p> 2011-10-10 http://hdl.handle.net/20.500.12678/0000003140 https://meral.edu.mm/records/3140