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oai:meral.edu.mm:recid/3139 2021-12-13T06:41:11Z 1582963366982:1596631591423 user-um1

The presence of anti-basement membrane zone antibodies in the sera of patients with non-buUous lupus erythematosus O. Ishikawa K.K. Zaw Y. Miyachi T. Hashimoto T. Tanaka <p>We performed indirect immunotluorescence (IF) studies using 1 mol/1 sodium chloride split skin to&nbsp;determine whether or not a positive IF is specific to patients with hullous kipus erythematosus (LE).&nbsp;We examined the sera from 21 patients with systemic LE (SLE). three of which were ohtained from&nbsp;two SLE patients and one subacute cutaneous LE (SCLE) patient with bullous eruptions. As a&nbsp;comparison, we also studied the sera from patients with discoid LE (DLE. u = 71. SCLE (n = 1). systemic&nbsp;sclerosis fSSc. n = 20), hullous pemphigoid (n = 2) and normal individuals (n &mdash; 10). Sera from 16 SLE.&nbsp;four DLE and two SSc revealed a linear deposition of IgG isotype antibody at the epidermal side and/or&nbsp;the dermal side on indirect IF of split skin. The sera from three patients with bullous eruption and from&nbsp;12 patients of SLE. SCLE. DLE without bullous eruption or SSc were further analysed by immunoblotting&nbsp;using live defined antigens, i.e. dermal extract, epidennal extract, three fusion proteins of 2 30 kDa&nbsp;bullous pemphigoid antigen (BPAG). 180 kDa BPAG. and human epidermolysis bullosa acquisita (EBA)&nbsp;antigen.</p> 1997-06-04 http://hdl.handle.net/20.500.12678/0000003139 https://meral.edu.mm/records/3139